Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1853822..1854339 Replicon chromosome
Accession NZ_CP026068
Organism Staphylococcus aureus strain FDAARGOS_24

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RK82_RS09670 Protein ID WP_000113262.1
Coordinates 1853822..1854088 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK82_RS09675 Protein ID WP_000584499.1
Coordinates 1854088..1854339 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK82_RS09640 1849248..1849784 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
RK82_RS09645 1850017..1850841 - 825 WP_000572040.1 formate/nitrite transporter family protein -
RK82_RS09650 1851058..1851240 - 183 WP_000230294.1 hypothetical protein -
RK82_RS09655 1851324..1851791 - 468 WP_000153344.1 SRPBCC domain-containing protein -
RK82_RS09660 1851977..1853527 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK82_RS09665 1853716..1853787 - 72 Protein_1780 hypothetical protein -
RK82_RS09670 1853822..1854088 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RK82_RS09675 1854088..1854339 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK82_RS09680 1854504..1854605 - 102 WP_001791744.1 hypothetical protein -
RK82_RS09685 1854612..1855211 - 600 WP_000162813.1 DsbA family protein -
RK82_RS09690 1855230..1855592 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RK82_RS09695 1855847..1857097 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
RK82_RS09700 1857194..1857925 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK82_RS09705 1857922..1858641 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T93056 WP_000113262.1 NZ_CP026068:c1854088-1853822 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T93056 NZ_CP026068:c1854088-1853822 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT93056 WP_000584499.1 NZ_CP026068:c1854339-1854088 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT93056 NZ_CP026068:c1854339-1854088 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References