Detailed information of TA system TA093042

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2576161..2576468
• Replicon: chromosome
• Accession: NZ_CP026067
• Organism: Staphylococcus aureus strain FDAARGOS_21

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: RK79_RS13240
• Protein ID: WP_072357969.1
• Coordinates: 2576292..2576468 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2576161..2576300 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK79_RS13180	2571728..2571907	+	180	WP_000669791.1	hypothetical protein	-
RK79_RS13190	2572218..2572478	+	261	WP_001791826.1	hypothetical protein	-
RK79_RS13195	2572530..2572880	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK79_RS13200	2573391..2573726	-	336	Protein_2448	SH3 domain-containing protein	-
RK79_RS13220	2574377..2574868	-	492	WP_000920038.1	staphylokinase	-
RK79_RS13225	2575059..2575814	-	756	WP_000861038.1	CHAP domain-containing protein	-
RK79_RS13230	2575826..2576080	-	255	WP_000611512.1	phage holin	-
RK79_RS13235	2576132..2576239	+	108	WP_031762631.1	hypothetical protein	-
-	2576161..2576300	+	140	NuclAT_0	-	Antitoxin
-	2576161..2576300	+	140	NuclAT_0	-	Antitoxin
-	2576161..2576300	+	140	NuclAT_0	-	Antitoxin
-	2576161..2576300	+	140	NuclAT_0	-	Antitoxin
RK79_RS13240	2576292..2576468	-	177	WP_072357969.1	putative holin-like toxin	Toxin
RK79_RS13245	2576611..2576985	-	375	WP_000340977.1	hypothetical protein	-
RK79_RS13250	2577041..2577328	-	288	WP_001040255.1	hypothetical protein	-
RK79_RS13255	2577375..2577527	-	153	WP_000654329.1	hypothetical protein	-
RK79_RS13260	2577517..2581302	-	3786	WP_047213611.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / groEL	2572530..2654598	82068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T93042 WP_072357969.1 NZ_CP026067:c2576468-2576292 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93042 NZ_CP026067:c2576468-2576292 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT93042 NZ_CP026067:2576161-2576300 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin