Detailed information of TA system TA093038

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2088070..2088649
• Replicon: chromosome
• Accession: NZ_CP026067
• Organism: Staphylococcus aureus strain FDAARGOS_21

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RK79_RS10510
• Protein ID: WP_001025401.1
• Coordinates: 2088404..2088649 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2088070..2088435 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK79_RS10470	2084812..2085369	-	558	WP_047213475.1	DUF2815 family protein	-
RK79_RS10475	2085395..2086561	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
RK79_RS10480	2086558..2086920	-	363	WP_000279452.1	hypothetical protein	-
RK79_RS10485	2086935..2087258	-	324	WP_000174996.1	hypothetical protein	-
RK79_RS10490	2087338..2087499	-	162	WP_001285961.1	DUF1270 domain-containing protein	-
RK79_RS10495	2087512..2087775	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RK79_RS10500	2087800..2088015	-	216	WP_001097552.1	hypothetical protein	-
RK79_RS10505	2088070..2088435	+	366	WP_047213477.1	hypothetical protein	Antitoxin
RK79_RS10510	2088404..2088649	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RK79_RS10515	2088699..2088917	-	219	WP_001001383.1	hypothetical protein	-
RK79_RS10520	2088933..2089488	-	556	Protein_1976	phage antirepressor KilAC domain-containing protein	-
RK79_RS10525	2089514..2089741	-	228	WP_001030311.1	hypothetical protein	-
RK79_RS10530	2089913..2090527	+	615	WP_000801423.1	XRE family transcriptional regulator	-
RK79_RS10535	2090543..2091463	+	921	WP_000348133.1	3'-5' exoribonuclease	-
RK79_RS10540	2091559..2091741	+	183	WP_000705240.1	hypothetical protein	-
RK79_RS10545	2091777..2091923	+	147	WP_001794606.1	hypothetical protein	-
RK79_RS10550	2091920..2092534	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	2046557..2121350	74793

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T93038 WP_001025401.1 NZ_CP026067:c2088649-2088404 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T93038 NZ_CP026067:c2088649-2088404 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT93038 NZ_CP026067:2088070-2088435 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAC
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin