Detailed information of TA system TA093037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2081039..2081462
• Replicon: chromosome
• Accession: NZ_CP026067
• Organism: Staphylococcus aureus strain FDAARGOS_21

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: RK79_RS10435
• Protein ID: WP_047213471.1
• Coordinates: 2081211..2081462 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A0E1X568
• Locus tag: RK79_RS10430
• Protein ID: WP_000028425.1
• Coordinates: 2081039..2081221 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK79_RS10390	2076432..2076722	-	291	WP_000665205.1	VRR-NUC domain-containing protein	-
RK79_RS10395	2076856..2076960	+	105	WP_015978074.1	hypothetical protein	-
RK79_RS10400	2077063..2079510	-	2448	WP_015994231.1	virulence-associated E family protein	-
RK79_RS10405	2079563..2079763	-	201	WP_000265258.1	DUF1514 family protein	-
RK79_RS10410	2079831..2079983	-	153	WP_000595237.1	transcriptional activator RinB	-
RK79_RS10415	2079976..2080212	-	237	WP_000483477.1	hypothetical protein	-
RK79_RS10420	2080237..2080473	-	237	WP_000195806.1	DUF1381 domain-containing protein	-
RK79_RS10425	2080510..2081046	-	537	WP_000185703.1	dUTPase	-
RK79_RS10430	2081039..2081221	-	183	WP_000028425.1	hypothetical protein	Antitoxin
RK79_RS10435	2081211..2081462	-	252	WP_047213471.1	DUF1024 family protein	Toxin
RK79_RS10440	2081477..2081719	-	243	WP_000132194.1	hypothetical protein	-
RK79_RS10445	2081734..2081934	-	201	WP_000235324.1	hypothetical protein	-
RK79_RS10450	2081937..2082194	-	258	WP_047213473.1	DUF3310 domain-containing protein	-
RK79_RS10455	2082194..2082595	-	402	WP_000113974.1	PVL family protein	-
RK79_RS10460	2082595..2082779	-	185	Protein_1964	DUF3113 family protein	-
RK79_RS10465	2082792..2084744	-	1953	WP_001802096.1	DNA polymerase	-
RK79_RS10470	2084812..2085369	-	558	WP_047213475.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	2046557..2121350	74793

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9419.35 Da
• Isoelectric Point: 3.8051

>T93037 WP_047213471.1 NZ_CP026067:c2081462-2081211 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T93037 NZ_CP026067:c2081462-2081211 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6781.65 Da
• Isoelectric Point: 4.4421

>AT93037 WP_000028425.1 NZ_CP026067:c2081221-2081039 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Nucleotide

• Length: 183 bp

>AT93037 NZ_CP026067:c2081221-2081039 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E1X568