Detailed information of TA system TA093026

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2645594..2645893
• Replicon: chromosome
• Accession: NZ_CP026066
• Organism: Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK78_RS13510
• Protein ID: WP_011447039.1
• Coordinates: 2645717..2645893 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2645594..2645649 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK78_RS13465	2640925..2641185	+	261	WP_001791826.1	hypothetical protein	-
RK78_RS13470	2641238..2641588	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK78_RS13475	2642273..2642722	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
RK78_RS13480	2642817..2643152	-	336	Protein_2521	SH3 domain-containing protein	-
RK78_RS13490	2643802..2644293	-	492	WP_000919350.1	staphylokinase	-
RK78_RS13495	2644484..2645239	-	756	WP_000861038.1	CHAP domain-containing protein	-
RK78_RS13500	2645251..2645505	-	255	WP_000611512.1	phage holin	-
RK78_RS13505	2645557..2645664	+	108	WP_001791821.1	hypothetical protein	-
-	2645586..2645725	+	140	NuclAT_0	-	-
-	2645586..2645725	+	140	NuclAT_0	-	-
-	2645586..2645725	+	140	NuclAT_0	-	-
-	2645586..2645725	+	140	NuclAT_0	-	-
-	2645594..2645649	+	56	-	-	Antitoxin
RK78_RS13510	2645717..2645893	-	177	WP_011447039.1	putative holin-like toxin	Toxin
RK78_RS13515	2646043..2646339	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
RK78_RS13520	2646397..2646684	-	288	WP_001040261.1	hypothetical protein	-
RK78_RS13525	2646731..2646883	-	153	WP_001153681.1	hypothetical protein	-
RK78_RS13530	2646873..2650658	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2641238..2669631	28393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T93026 WP_011447039.1 NZ_CP026066:c2645893-2645717 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93026 NZ_CP026066:c2645893-2645717 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT93026 NZ_CP026066:2645594-2645649 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin