Detailed information of TA system TA093022

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2490034..2490214
• Replicon: chromosome
• Accession: NZ_CP026066
• Organism: Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: RK78_RS14425
• Protein ID: WP_001801861.1
• Coordinates: 2490034..2490129 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2490157..2490214 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK78_RS12475	2485178..2485804	+	627	WP_031883263.1	hypothetical protein	-
RK78_RS12480	2485845..2486189	+	345	WP_000627550.1	DUF3969 family protein	-
RK78_RS12485	2486287..2486859	+	573	WP_000414222.1	hypothetical protein	-
RK78_RS12490	2487008..2488375	-	1368	WP_001093573.1	FRG domain-containing protein	-
RK78_RS12495	2488375..2488944	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
RK78_RS12500	2489137..2489583	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
RK78_RS14425	2490034..2490129	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2490157..2490214	-	58	-	-	Antitoxin
RK78_RS12510	2490252..2490353	+	102	WP_001791232.1	hypothetical protein	-
RK78_RS12515	2490528..2490971	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
RK78_RS12520	2490971..2491414	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
RK78_RS12525	2491414..2491856	-	443	Protein_2375	DUF1433 domain-containing protein	-
RK78_RS12530	2492381..2494801	+	2421	WP_000182551.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T93022 WP_001801861.1 NZ_CP026066:2490034-2490129 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T93022 NZ_CP026066:2490034-2490129 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT93022 NZ_CP026066:c2490214-2490157 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin