Detailed information of TA system TA093018

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2162153..2162732
• Replicon: chromosome
• Accession: NZ_CP026066
• Organism: Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: RK78_RS10840
• Protein ID: WP_000701494.1
• Coordinates: 2162487..2162732 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2162153..2162518 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK78_RS10800	2158896..2159453	-	558	WP_000645042.1	DUF2815 family protein	-
RK78_RS10805	2159479..2160645	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
RK78_RS10810	2160642..2161004	-	363	WP_000279449.1	hypothetical protein	-
RK78_RS10815	2161019..2161342	-	324	WP_000175000.1	hypothetical protein	-
RK78_RS10820	2161421..2161582	-	162	WP_001285963.1	DUF1270 family protein	-
RK78_RS10825	2161595..2161858	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
RK78_RS10830	2161883..2162098	-	216	WP_001036302.1	hypothetical protein	-
RK78_RS10835	2162153..2162518	+	366	WP_001128433.1	hypothetical protein	Antitoxin
RK78_RS10840	2162487..2162732	-	246	WP_000701494.1	DUF2829 domain-containing protein	Toxin
RK78_RS10845	2162788..2162997	+	210	WP_000642492.1	hypothetical protein	-
RK78_RS10850	2162987..2163130	-	144	WP_000939498.1	hypothetical protein	-
RK78_RS10855	2163159..2163935	-	777	WP_001148544.1	Rha family transcriptional regulator	-
RK78_RS10860	2163949..2164185	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
RK78_RS10865	2164337..2164651	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
RK78_RS10870	2164664..2165125	+	462	WP_000525004.1	hypothetical protein	-
RK78_RS10875	2165143..2165727	+	585	WP_000825948.1	hypothetical protein	-
RK78_RS10880	2165957..2166103	+	147	WP_001013104.1	hypothetical protein	-
RK78_RS10885	2166100..2166714	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	2121977..2180820	58843

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (3-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9482.79 Da
• Isoelectric Point: 6.9769

>T93018 WP_000701494.1 NZ_CP026066:c2162732-2162487 [Staphylococcus aureus]
MKIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T93018 NZ_CP026066:c2162732-2162487 [Staphylococcus aureus]
ATGAAAATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT93018 NZ_CP026066:2162153-2162518 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Antitoxin