Detailed information of TA system TA093017

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1591959..1592208
• Replicon: chromosome
• Accession: NZ_CP026066
• Organism: Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: RK78_RS08000
• Protein ID: WP_000623369.1
• Coordinates: 1591959..1592066 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1592061..1592208 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK78_RS07975	1588632..1589201	-	570	WP_000287265.1	competence protein ComK	-
RK78_RS07980	1589411..1589629	+	219	WP_000876825.1	IDEAL domain-containing protein	-
RK78_RS07985	1589710..1590696	-	987	WP_000668820.1	lipoate--protein ligase	-
RK78_RS07990	1590895..1591071	+	177	WP_000214898.1	YkvS family protein	-
RK78_RS07995	1591086..1591688	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
RK78_RS08000	1591959..1592066	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	1592061..1592208	-	148	-	-	Antitoxin
RK78_RS08005	1592605..1592706	+	102	WP_001790623.1	hypothetical protein	-
RK78_RS08010	1592716..1592988	+	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
RK78_RS08015	1593032..1594996	+	1965	WP_000870819.1	bacteriocin-associated integral membrane family protein	-
RK78_RS08020	1594999..1595319	+	321	WP_000873929.1	YxeA family protein	-
RK78_RS08025	1595316..1595957	+	642	WP_000571183.1	ABC transporter ATP-binding protein	-
RK78_RS08030	1596045..1596335	-	291	WP_001791476.1	hypothetical protein	-
RK78_RS08035	1596676..1596963	+	288	WP_000410718.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T93017 WP_000623369.1 NZ_CP026066:1591959-1592066 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T93017 NZ_CP026066:1591959-1592066 [Staphylococcus aureus]
GTGATATCTATTGCAAACGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT93017 NZ_CP026066:c1592208-1592061 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTTCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin