Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 238380..238897 Replicon chromosome
Accession NZ_CP026066
Organism Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag RK78_RS01335 Protein ID WP_000251928.1
Coordinates 238380..238646 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag RK78_RS01340 Protein ID WP_000584497.1
Coordinates 238646..238897 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK78_RS01310 233587..234123 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
RK78_RS01315 234591..235415 - 825 WP_000594640.1 formate/nitrite transporter family protein -
RK78_RS01320 235618..235800 - 183 WP_000079140.1 hypothetical protein -
RK78_RS01325 235887..236354 - 468 WP_000153340.1 SRPBCC domain-containing protein -
RK78_RS01330 236540..238087 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK78_RS01335 238380..238646 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
RK78_RS01340 238646..238897 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK78_RS01345 239061..239161 - 101 Protein_253 hypothetical protein -
RK78_RS01350 239168..239767 - 600 WP_000162804.1 DsbA family protein -
RK78_RS01355 239786..240148 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RK78_RS01360 240403..241653 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
RK78_RS01365 241750..242481 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
RK78_RS01370 242478..243197 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T93012 WP_000251928.1 NZ_CP026066:c238646-238380 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T93012 NZ_CP026066:c238646-238380 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT93012 WP_000584497.1 NZ_CP026066:c238897-238646 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT93012 NZ_CP026066:c238897-238646 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References