Detailed information of TA system TA093009

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2760568..2760906
• Replicon: chromosome
• Accession: NZ_CP026064
• Organism: Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK77_RS14305
• Protein ID: WP_011447039.1
• Coordinates: 2760568..2760744 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2760732..2760906 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK77_RS14275	2755842..2756132	+	291	WP_000179858.1	hypothetical protein	-
RK77_RS14280	2756148..2758058	+	1911	WP_000429558.1	minor structural protein	-
RK77_RS14285	2758058..2759524	+	1467	WP_000067127.1	BppU family phage baseplate upper protein	-
RK77_RS14290	2759524..2759913	+	390	WP_001166596.1	DUF2977 domain-containing protein	-
RK77_RS14295	2759906..2760070	+	165	WP_000916020.1	XkdX family protein	-
RK77_RS14300	2760116..2760415	+	300	WP_000466784.1	DUF2951 domain-containing protein	-
RK77_RS14305	2760568..2760744	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2760732..2760906	-	175	-	-	Antitoxin
RK77_RS14315	2760956..2761210	+	255	WP_000611512.1	phage holin	-
RK77_RS14320	2761222..2761977	+	756	WP_000861038.1	CHAP domain-containing protein	-
RK77_RS14325	2762338..2764242	+	1905	WP_001003363.1	N-6 DNA methylase	-
RK77_RS14330	2764229..2765239	+	1011	WP_000777019.1	restriction endonuclease subunit S	-
RK77_RS15040	2765418..2765633	+	216	WP_170267452.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2715843..2765633	49790

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T93009 WP_011447039.1 NZ_CP026064:2760568-2760744 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93009 NZ_CP026064:2760568-2760744 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT93009 NZ_CP026064:c2760906-2760732 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin