Detailed information of TA system TA093006

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2723924..2724503
• Replicon: chromosome
• Accession: NZ_CP026064
• Organism: Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RK77_RS14055
• Protein ID: WP_001025401.1
• Coordinates: 2723924..2724169 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2724138..2724503 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK77_RS14010	2720173..2720787	+	615	WP_000191464.1	hypothetical protein	-
RK77_RS14015	2720784..2720930	-	147	WP_001795334.1	hypothetical protein	-
RK77_RS14020	2720967..2721149	-	183	WP_000705240.1	hypothetical protein	-
RK77_RS14025	2721220..2721951	-	732	WP_000511090.1	XRE family transcriptional regulator	-
RK77_RS14030	2722103..2722315	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
RK77_RS14035	2722363..2722806	+	444	WP_000435357.1	hypothetical protein	-
RK77_RS14985	2722821..2722970	+	150	WP_000771849.1	hypothetical protein	-
RK77_RS14040	2723011..2723223	-	213	WP_000362644.1	hypothetical protein	-
RK77_RS14045	2723293..2723490	+	198	WP_001148860.1	hypothetical protein	-
RK77_RS14050	2723477..2723857	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
RK77_RS14055	2723924..2724169	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RK77_RS14060	2724138..2724503	-	366	WP_001128433.1	hypothetical protein	Antitoxin
RK77_RS14065	2724558..2724773	+	216	WP_001097552.1	hypothetical protein	-
RK77_RS14070	2724798..2725061	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RK77_RS14075	2725074..2725235	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
RK77_RS14080	2725314..2725637	+	324	WP_000175000.1	hypothetical protein	-
RK77_RS14085	2725652..2726014	+	363	WP_000985986.1	hypothetical protein	-
RK77_RS14090	2726011..2727177	+	1167	WP_000762534.1	DUF2800 domain-containing protein	-
RK77_RS14095	2727203..2727757	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2715843..2765633	49790

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T93006 WP_001025401.1 NZ_CP026064:2723924-2724169 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T93006 NZ_CP026064:2723924-2724169 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT93006 NZ_CP026064:c2724503-2724138 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin