Detailed information of TA system TA093000

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2240576..2240914
• Replicon: chromosome
• Accession: NZ_CP026064
• Organism: Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK77_RS11345
• Protein ID: WP_011447039.1
• Coordinates: 2240576..2240752 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2240740..2240914 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK77_RS11325	2235811..2239596	+	3786	WP_000582168.1	hypothetical protein	-
RK77_RS11330	2239586..2239738	+	153	WP_001153681.1	hypothetical protein	-
RK77_RS11335	2239785..2240072	+	288	WP_001040261.1	hypothetical protein	-
RK77_RS11340	2240130..2240426	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
RK77_RS11345	2240576..2240752	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2240740..2240914	-	175	-	-	Antitoxin
RK77_RS11355	2240964..2241218	+	255	WP_000611512.1	phage holin	-
RK77_RS11360	2241230..2241985	+	756	WP_000861039.1	CHAP domain-containing protein	-
RK77_RS11365	2242176..2242667	+	492	WP_000919349.1	staphylokinase	-
RK77_RS11375	2243317..2243652	+	336	Protein_2145	SH3 domain-containing protein	-
RK77_RS11380	2243747..2244196	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
RK77_RS11385	2244881..2245231	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK77_RS11390	2245284..2245544	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2185533..2245231	59698

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T93000 WP_011447039.1 NZ_CP026064:2240576-2240752 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93000 NZ_CP026064:2240576-2240752 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT93000 NZ_CP026064:c2240914-2240740 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin