Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1801976..1802493 Replicon chromosome
Accession NZ_CP026064
Organism Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag RK77_RS08900 Protein ID WP_000113261.1
Coordinates 1802227..1802493 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK77_RS08895 Protein ID WP_000584499.1
Coordinates 1801976..1802227 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK77_RS08865 1797688..1798407 + 720 WP_000479573.1 amino acid ABC transporter permease -
RK77_RS08870 1798404..1799135 + 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
RK77_RS08875 1799220..1800470 - 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
RK77_RS08880 1800725..1801087 + 363 WP_000819843.1 DUF4467 domain-containing protein -
RK77_RS08885 1801106..1801705 + 600 WP_000162810.1 DsbA family protein -
RK77_RS08890 1801712..1801813 + 102 Protein_1678 hypothetical protein -
RK77_RS08895 1801976..1802227 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK77_RS08900 1802227..1802493 + 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
RK77_RS08905 1802787..1804337 + 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK77_RS08910 1804523..1804990 + 468 WP_000153345.1 SRPBCC domain-containing protein -
RK77_RS08915 1805077..1805259 + 183 WP_000250735.1 hypothetical protein -
RK77_RS08920 1805462..1806286 + 825 WP_000594637.1 formate/nitrite transporter family protein -
RK77_RS08925 1806520..1807056 + 537 WP_000169319.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T92993 WP_000113261.1 NZ_CP026064:1802227-1802493 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

>T92993 NZ_CP026064:1802227-1802493 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT92993 WP_000584499.1 NZ_CP026064:1801976-1802227 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT92993 NZ_CP026064:1801976-1802227 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References