Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1744019..1744542 Replicon chromosome
Accession NZ_CP026064
Organism Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag RK77_RS08590 Protein ID WP_000074048.1
Coordinates 1744276..1744542 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag RK77_RS08585 Protein ID WP_000587616.1
Coordinates 1744019..1744276 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK77_RS08565 1740516..1741265 - 750 WP_000072439.1 hypothetical protein -
RK77_RS08570 1741460..1743037 + 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
RK77_RS08575 1743205..1743660 - 456 WP_000732088.1 DUF1307 domain-containing protein -
RK77_RS08585 1744019..1744276 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK77_RS08590 1744276..1744542 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
RK77_RS08595 1744897..1745973 + 1077 WP_001076688.1 M42 family metallopeptidase -
RK77_RS08600 1746319..1746981 + 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
RK77_RS08605 1746974..1747750 + 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
RK77_RS08610 1748144..1749331 + 1188 WP_000026196.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T92990 WP_000074048.1 NZ_CP026064:1744276-1744542 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T92990 NZ_CP026064:1744276-1744542 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT92990 WP_000587616.1 NZ_CP026064:1744019-1744276 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT92990 NZ_CP026064:1744019-1744276 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References