Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 524415..524932 Replicon chromosome
Accession NZ_CP026063
Organism Staphylococcus aureus strain FDAARGOS_14

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag RK72_RS03020 Protein ID WP_000113265.1
Coordinates 524415..524681 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK72_RS03025 Protein ID WP_000584499.1
Coordinates 524681..524932 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK72_RS02990 519843..520379 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
RK72_RS02995 520613..521437 - 825 WP_000572035.1 formate/nitrite transporter family protein -
RK72_RS03000 521654..521836 - 183 WP_000230292.1 hypothetical protein -
RK72_RS03005 521920..522387 - 468 WP_000153347.1 SRPBCC domain-containing protein -
RK72_RS03010 522573..524120 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK72_RS03015 524309..524380 - 72 Protein_547 hypothetical protein -
RK72_RS03020 524415..524681 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
RK72_RS03025 524681..524932 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK72_RS03030 525097..525198 - 102 Protein_550 hypothetical protein -
RK72_RS03035 525205..525804 - 600 WP_000162810.1 DsbA family protein -
RK72_RS03040 525823..526185 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RK72_RS03045 526440..527690 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
RK72_RS03050 527787..528518 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK72_RS03055 528515..529234 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T92981 WP_000113265.1 NZ_CP026063:c524681-524415 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T92981 NZ_CP026063:c524681-524415 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT92981 WP_000584499.1 NZ_CP026063:c524932-524681 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT92981 NZ_CP026063:c524932-524681 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References