Detailed information of TA system TA092954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4799568..4800228
• Replicon: chromosome
• Accession: NZ_CP026050
• Organism: Serratia marcescens strain FDAARGOS_65

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MC51_RS22585
• Protein ID: WP_047571347.1
• Coordinates: 4799568..4799921 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2V4GQ69
• Locus tag: MC51_RS22590
• Protein ID: WP_033635213.1
• Coordinates: 4799926..4800228 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC51_RS22565	4795667..4796032	+	366	WP_033635218.1	diacylglycerol kinase	-
MC51_RS22570	4796125..4797024	+	900	WP_047571342.1	LysR family transcriptional regulator	-
MC51_RS22575	4796999..4797805	-	807	WP_043147694.1	substrate-binding domain-containing protein	-
MC51_RS22580	4797833..4799128	-	1296	WP_047571345.1	MFS transporter	-
MC51_RS22585	4799568..4799921	+	354	WP_047571347.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC51_RS22590	4799926..4800228	+	303	WP_033635213.1	XRE family transcriptional regulator	Antitoxin
MC51_RS22595	4800491..4803433	-	2943	WP_052133530.1	salicylate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13601.51 Da
• Isoelectric Point: 9.4805

>T92954 WP_047571347.1 NZ_CP026050:4799568-4799921 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPRLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTNWLNTLNEKE

Nucleotide

• Length: 354 bp

>T92954 NZ_CP026050:4799568-4799921 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGATCCTGCGGGAAAAGGGGCCGAGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTACTTTGCGCGGGCAATAAAGCCGGCAATGAAAAGCGTTTTTACGATCGAATGCTTCAGATTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11079.94 Da
• Isoelectric Point: 6.4738

>AT92954 WP_033635213.1 NZ_CP026050:4799926-4800228 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT92954 NZ_CP026050:4799926-4800228 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCGGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCGGACGGCTCTCACTACGAATTTGTGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2V4GQ69