Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4011828..4012480 Replicon chromosome
Accession NZ_CP026050
Organism Serratia marcescens strain FDAARGOS_65

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag MC51_RS18855 Protein ID WP_033635775.1
Coordinates 4012136..4012480 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag MC51_RS18850 Protein ID WP_004931828.1
Coordinates 4011828..4012130 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC51_RS18825 4006836..4007483 - 648 WP_047570698.1 DsbA family protein -
MC51_RS18830 4007552..4008436 - 885 WP_033635778.1 MBL fold metallo-hydrolase -
MC51_RS18835 4008545..4009453 + 909 WP_015378928.1 LysR family transcriptional regulator -
MC51_RS18840 4009481..4010404 - 924 WP_033654101.1 LysR family transcriptional regulator -
MC51_RS18845 4010538..4011800 + 1263 WP_047570701.1 diaminopimelate decarboxylase -
MC51_RS18850 4011828..4012130 - 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
MC51_RS18855 4012136..4012480 - 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MC51_RS18860 4012640..4013659 - 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
MC51_RS18865 4013880..4016138 + 2259 WP_047570704.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T92952 WP_033635775.1 NZ_CP026050:c4012480-4012136 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T92952 NZ_CP026050:c4012480-4012136 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACACCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCA
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT92952 WP_004931828.1 NZ_CP026050:c4012130-4011828 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT92952 NZ_CP026050:c4012130-4011828 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAACACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References