Detailed information of TA system TA092947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2445698..2446351
• Replicon: chromosome
• Accession: NZ_CP026050
• Organism: Serratia marcescens strain FDAARGOS_65

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MC51_RS11550
• Protein ID: WP_047569495.1
• Coordinates: 2446001..2446351 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A5C7DBM3
• Locus tag: MC51_RS11545
• Protein ID: WP_019453270.1
• Coordinates: 2445698..2445997 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC51_RS11520	2441119..2442042	-	924	WP_047569489.1	3-hydroxyacyl-CoA dehydrogenase family protein	-
MC51_RS11525	2442061..2443245	-	1185	WP_047569491.1	acetyl-CoA C-acetyltransferase	-
MC51_RS11530	2443259..2443912	-	654	WP_041037752.1	CoA transferase subunit B	-
MC51_RS11535	2443924..2444622	-	699	WP_033648567.1	CoA transferase subunit A	-
MC51_RS11540	2444791..2445708	+	918	WP_033636930.1	LysR family transcriptional regulator	-
MC51_RS11545	2445698..2445997	-	300	WP_019453270.1	XRE family transcriptional regulator	Antitoxin
MC51_RS11550	2446001..2446351	-	351	WP_047569495.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC51_RS11555	2446622..2447627	+	1006	Protein_2263	hypothetical protein	-
MC51_RS11565	2448044..2448436	+	393	WP_047569497.1	hypothetical protein	-
MC51_RS11570	2448450..2448845	+	396	WP_047569499.1	hypothetical protein	-
MC51_RS11575	2448836..2449153	-	318	WP_047569501.1	hypothetical protein	-
MC51_RS11580	2449399..2450769	+	1371	WP_041037742.1	glutamine synthetase family protein	-
MC51_RS11585	2450798..2451208	+	411	WP_033636925.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-83)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13560.84 Da
• Isoelectric Point: 8.2699

>T92947 WP_047569495.1 NZ_CP026050:c2446351-2446001 [Serratia marcescens]
MWTIMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHPNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQYLMCYFKE

Nucleotide

• Length: 351 bp

>T92947 NZ_CP026050:c2446351-2446001 [Serratia marcescens]
ATGTGGACGATAATGACAACGGAAGAGTTTGATCGGTGGCTCTGTGAGCAGGATGAATCGACGCAGGAAAAGGTGTTGGC
CGCGCTGGTGATGCTCGAGCGTGCCGGGCCTTCTCTCCGGCGGCCTTTTGTCGACGTGCTGAAAGGTTCGTTGCATCCCA
ACATGAAAGAGCTGCGTATTCAGCACAAAGGGCGGCCGATTCGCGCTTTTTTCGCCTTCGATCCGGCGCGGCAGGCGATT
GTGCTGTGTGCGGGCGACAAAACGGGTAATGAGAAGCGGTTTTATAAAGTGATGCTGCCCATCGCGGATGCGCAGTTCAC
CCAATATTTGATGTGTTATTTCAAGGAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11013.71 Da
• Isoelectric Point: 7.3207

>AT92947 WP_019453270.1 NZ_CP026050:c2445997-2445698 [Serratia marcescens]
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKTLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV

Nucleotide

• Length: 300 bp

>AT92947 NZ_CP026050:c2445997-2445698 [Serratia marcescens]
ATGAGCACCTTAAAGCAACTGCTGGCCTCCCGCACCCCGGAGAGCCGCCGGCGCATCGAGGAAATGGCCGAAGAGATGCT
GTTTGAAGCGCACCTGCACCAGCTGCGGGAAGCGCTGAATATTTCCCAACAGGAACTGGCGAAAACGCTGGGCATTTCCC
AGCCTTCGGTCGCGGCCATCGAAGGGCGCGGCAACGAGCTGAAGATTTCGACCCTGAAACGCTACGTGGAAGCGATGGGC
GGCACGCTGCGCCTGGACGTTGAGCTGCCGGGCGGCAAGCACGTCGGGTTTACGGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DBM3