Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 956906..957505 Replicon chromosome
Accession NZ_CP026045
Organism Citrobacter freundii strain FDAARGOS_61

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MC47_RS04730 Protein ID WP_047407483.1
Coordinates 957194..957505 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MC47_RS04725 Protein ID WP_047407480.1
Coordinates 956906..957193 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC47_RS04710 954402..955304 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
MC47_RS04715 955301..955936 + 636 WP_047407477.1 formate dehydrogenase cytochrome b556 subunit -
MC47_RS04720 955933..956862 + 930 WP_043018887.1 formate dehydrogenase accessory protein FdhE -
MC47_RS04725 956906..957193 - 288 WP_047407480.1 helix-turn-helix domain-containing protein Antitoxin
MC47_RS04730 957194..957505 - 312 WP_047407483.1 hypothetical protein Toxin
MC47_RS04735 957726..958634 + 909 WP_047407486.1 alpha/beta hydrolase -
MC47_RS04740 958699..958941 + 243 WP_003825282.1 type II toxin-antitoxin system ParD family antitoxin -
MC47_RS04745 958934..959221 + 288 WP_003825284.1 type II toxin-antitoxin system RelE/ParE family toxin -
MC47_RS04750 959227..960168 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
MC47_RS04755 960213..960650 - 438 WP_003028671.1 D-tyrosyl-tRNA(Tyr) deacylase -
MC47_RS04760 960647..961519 - 873 WP_047407489.1 virulence factor BrkB family protein -
MC47_RS04765 961513..962112 - 600 WP_043018883.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12270.39 Da        Isoelectric Point: 10.0972

>T92904 WP_047407483.1 NZ_CP026045:c957505-957194 [Citrobacter freundii]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLTIQPDCGDLIHDTGGLRKVRWRARGKGKRGGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNEGW

Download         Length: 312 bp

>T92904 NZ_CP026045:c957505-957194 [Citrobacter freundii]
ATGCTATTCATAGAAACGGAAATCTTTACTGAAGACGTCAAAAAATTACTGGATGATGATGAATACCGTAGACTACAGAT
ATTCCTTACGATTCAGCCCGATTGTGGCGATCTGATACATGATACAGGGGGCCTGAGAAAGGTTCGCTGGAGAGCGCGAG
GGAAAGGAAAACGTGGCGGTGTAAGGATTATCTACTTTCATCAAATCAGGAAATCACAAATTCGTTTGTTGCTGATTTAT
CAGAAAGGGATCAAGGATGATCTGACTCCACAGGAAAAAGTACTGCTGCGTATGTTGAATGAGGGGTGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10819.40 Da        Isoelectric Point: 10.8907

>AT92904 WP_047407480.1 NZ_CP026045:c957193-956906 [Citrobacter freundii]
MDKALFERLTQSMIQMNEIDEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp

>AT92904 NZ_CP026045:c957193-956906 [Citrobacter freundii]
ATGGATAAGGCACTATTTGAGCGATTAACTCAAAGTATGATTCAGATGAATGAGATCGATGAAGGAACGCGGCAGCCTTC
TCGTACCTTTCATATTGACGCCATGAAAATAAAGGAAATCCGCCAGTCTTCAGGATTATCACAGACTCGTTTCGCAGATT
TGATATCGGTAAGCGTGGATACGTTGCGAAATTGGGAGCAGGGGCGTCGTTCACCGACCGGTCCAGCAAAAGCGTTGTTA
CGTGCCATTGCCAATGATCCAAAACATGTCATTCAGGCGCTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References