92772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2087235..2087737 Replicon chromosome
Accession NZ_CP026026
Organism Escherichia coli strain CAR

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C2H81_RS11085 Protein ID WP_000767829.1
Coordinates 2087235..2087489 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag C2H81_RS11090 Protein ID WP_001259255.1
Coordinates 2087486..2087737 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2H81_RS11055 2082250..2082477 - 228 WP_000234896.1 sulfurtransferase TusA -
C2H81_RS11060 2082491..2083549 - 1059 WP_000492339.1 transport protein YeeE -
C2H81_RS11065 2083728..2085086 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
C2H81_RS11070 2085076..2085138 - 63 WP_010723108.1 membrane protein YoeI -
C2H81_RS11075 2085353..2086282 - 930 WP_000803351.1 LysR family transcriptional regulator -
C2H81_RS11080 2086328..2087152 - 825 WP_000754737.1 SDR family oxidoreductase -
C2H81_RS11085 2087235..2087489 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C2H81_RS11090 2087486..2087737 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C2H81_RS11095 2088020..2088070 + 51 WP_001364200.1 his operon leader peptide -
C2H81_RS11105 2088216..2089115 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
C2H81_RS11110 2089121..2090425 + 1305 WP_000009594.1 histidinol dehydrogenase -
C2H81_RS11115 2090422..2091492 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
C2H81_RS11120 2091492..2092559 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T92772 WP_000767829.1 NZ_CP026026:c2087489-2087235 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T92772 NZ_CP026026:c2087489-2087235 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT92772 WP_001259255.1 NZ_CP026026:c2087737-2087486 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT92772 NZ_CP026026:c2087737-2087486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References