Detailed information of TA system TA092639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2293682..2294376
• Replicon: chromosome
• Accession: NZ_CP025987
• Organism: Marinomonas sp. FW-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: C1X04_RS10745
• Protein ID: WP_137169900.1
• Coordinates: 2293682..2294050 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C1X04_RS10750
• Protein ID: WP_110573128.1
• Coordinates: 2294062..2294376 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1X04_RS10735	2290024..2290503	-	480	WP_137169898.1	hypothetical protein	-
C1X04_RS10740	2291992..2293473	-	1482	WP_137169899.1	carboxypeptidase M32	-
C1X04_RS10745	2293682..2294050	+	369	WP_137169900.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C1X04_RS10750	2294062..2294376	+	315	WP_110573128.1	XRE family transcriptional regulator	Antitoxin
C1X04_RS10755	2294451..2296190	-	1740	WP_137169901.1	D-lactate dehydrogenase	-
C1X04_RS10760	2296318..2297190	-	873	WP_137170759.1	alpha/beta hydrolase	-
C1X04_RS10765	2297479..2298168	+	690	WP_137169902.1	DUF3800 domain-containing protein	-
C1X04_RS10770	2298227..2299093	-	867	WP_110573138.1	formyltetrahydrofolate deformylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (14-87)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 14351.43 Da
• Isoelectric Point: 6.9835

>T92639 WP_137169900.1 NZ_CP025987:2293682-2294050 [Marinomonas sp. FW-1]
MIWEILITDEYEQWFLGLTDKEQEDVLSMVDVLEIKGPQLARPYADSLKGTNKVKNLKELRVQHAGKPYRVFYAFDPTRK
AILLCGGRKDGRKDKTFYDRYIPLAEKEFLNYLKNSDSEETR

Nucleotide

• Length: 369 bp

>T92639 NZ_CP025987:2293682-2294050 [Marinomonas sp. FW-1]
ATGATTTGGGAGATATTAATAACCGACGAATACGAACAATGGTTTCTTGGCTTGACGGACAAAGAGCAAGAAGACGTGCT
ATCAATGGTTGATGTATTAGAGATCAAAGGTCCTCAATTAGCACGACCCTATGCAGATTCTCTAAAAGGAACAAATAAGG
TAAAGAACCTTAAAGAATTGAGAGTTCAGCATGCAGGAAAACCTTATCGTGTCTTTTATGCTTTTGACCCAACAAGGAAA
GCCATATTGCTATGTGGTGGCCGCAAAGATGGGAGAAAAGATAAAACATTTTATGATAGATATATTCCATTAGCTGAAAA
AGAATTCTTAAATTACTTGAAAAATAGTGATTCAGAAGAAACAAGATAG

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11410.28 Da
• Isoelectric Point: 8.5843

>AT92639 WP_110573128.1 NZ_CP025987:2294062-2294376 [Marinomonas sp. FW-1]
MAKSLNELREKIKPEVQAAARAKAVAIIAEMSLAEVRKKRGINQADLAGLMNIAQPNISQIENRPDALISTLNQYIEALG
GKLEIHAKFPDGQDIEISQFAMIK

Nucleotide

• Length: 315 bp

>AT92639 NZ_CP025987:2294062-2294376 [Marinomonas sp. FW-1]
ATGGCTAAGTCGCTCAACGAATTACGAGAGAAAATTAAACCAGAGGTTCAAGCCGCAGCTAGAGCTAAAGCTGTTGCCAT
TATTGCAGAGATGTCTCTTGCAGAAGTCAGAAAAAAAAGAGGCATAAATCAGGCAGATTTAGCAGGCCTTATGAATATTG
CTCAGCCAAACATCTCTCAAATTGAAAATCGTCCTGATGCCCTTATCAGTACATTGAATCAATATATTGAAGCATTGGGA
GGTAAGCTAGAAATACACGCCAAGTTCCCTGACGGACAAGACATAGAAATTTCTCAATTCGCAATGATTAAGTAA