Detailed information of TA system TA092636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1345179..1345795
• Replicon: chromosome
• Accession: NZ_CP025987
• Organism: Marinomonas sp. FW-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: C1X04_RS06330
• Protein ID: WP_175404909.1
• Coordinates: 1345179..1345466 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C1X04_RS06335
• Protein ID: WP_110571682.1
• Coordinates: 1345478..1345795 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1X04_RS06310	1340275..1342101	-	1827	WP_137169463.1	protein-disulfide reductase DsbD	-
C1X04_RS06315	1342187..1343023	+	837	WP_137169464.1	hypothetical protein	-
C1X04_RS06320	1343036..1344052	+	1017	WP_110571680.1	DUF2333 family protein	-
C1X04_RS06325	1344084..1344563	+	480	WP_137170736.1	GNAT family N-acetyltransferase	-
C1X04_RS06330	1345179..1345466	+	288	WP_175404909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C1X04_RS06335	1345478..1345795	+	318	WP_110571682.1	HigA family addiction module antidote protein	Antitoxin
C1X04_RS06340	1346917..1347771	+	855	WP_137169466.1	hypothetical protein	-
C1X04_RS06345	1348941..1349591	-	651	WP_110571683.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-69)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11501.16 Da
• Isoelectric Point: 7.3556

>T92636 WP_175404909.1 NZ_CP025987:1345179-1345466 [Marinomonas sp. FW-1]
MSLEFKHKWLELFYEEDQRHRLIPKNIENALYRKLEILDAALTESDLRIPPGNRFEHLDGNLQGWCSIRINKQYRLIFQW
VQGTALNTYLDPHKY

Nucleotide

• Length: 288 bp

>T92636 NZ_CP025987:1345179-1345466 [Marinomonas sp. FW-1]
ATGTCATTAGAATTTAAACATAAATGGTTAGAATTATTTTACGAAGAAGACCAGCGTCACAGGTTGATACCTAAGAATAT
TGAAAATGCTCTATATAGGAAGTTGGAAATTTTAGATGCGGCACTGACAGAGTCTGATTTACGGATTCCTCCAGGTAATC
GATTTGAGCATTTAGACGGTAATCTGCAAGGCTGGTGTTCAATTCGAATCAATAAACAATACCGCTTAATTTTTCAGTGG
GTCCAAGGAACTGCTCTAAACACTTATCTTGACCCGCACAAATATTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11721.72 Da
• Isoelectric Point: 10.3419

>AT92636 WP_110571682.1 NZ_CP025987:1345478-1345795 [Marinomonas sp. FW-1]
MRKTKRRPVSVGEMLKIEFLEPMNITSKALADAMGVHRNTVSSLINGGVLTAPIAIKLAAAFGNTPEFWLNIQHAVDLWD
TRNRYQEEAKLVKPLVVGKKEELHA

Nucleotide

• Length: 318 bp

>AT92636 NZ_CP025987:1345478-1345795 [Marinomonas sp. FW-1]
ATGCGTAAAACAAAACGTCGACCAGTTAGCGTTGGTGAAATGCTTAAAATTGAGTTTCTTGAACCAATGAACATTACCTC
CAAAGCACTGGCTGATGCTATGGGAGTACATCGTAATACCGTCAGCAGTCTTATCAACGGTGGTGTGCTAACCGCGCCAA
TCGCTATAAAACTAGCGGCTGCCTTTGGTAATACACCTGAATTTTGGTTAAACATACAACATGCTGTCGATCTTTGGGAT
ACACGAAACCGTTATCAAGAAGAAGCCAAACTGGTTAAGCCTTTGGTGGTGGGTAAGAAAGAAGAATTGCATGCATAA