Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 616292..616896 Replicon chromosome
Accession NZ_CP025987
Organism Marinomonas sp. FW-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C1X04_RS02830 Protein ID WP_110575961.1
Coordinates 616292..616609 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C1X04_RS02835 Protein ID WP_110575959.1
Coordinates 616606..616896 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1X04_RS02815 612439..613977 + 1539 WP_110575967.1 histidine ammonia-lyase -
C1X04_RS02820 613992..615212 + 1221 WP_110575965.1 imidazolonepropionase -
C1X04_RS02825 615227..616042 + 816 WP_110575963.1 N-formylglutamate deformylase -
C1X04_RS02830 616292..616609 + 318 WP_110575961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1X04_RS02835 616606..616896 + 291 WP_110575959.1 helix-turn-helix domain-containing protein Antitoxin
C1X04_RS02840 616934..617173 + 240 WP_110575957.1 DUF2442 domain-containing protein -
C1X04_RS02845 617492..618028 + 537 WP_110575955.1 DUF924 domain-containing protein -
C1X04_RS02850 618127..618783 - 657 WP_110575953.1 NAD(P)H-dependent oxidoreductase -
C1X04_RS02855 618958..619908 + 951 WP_110575951.1 LysR family transcriptional regulator -
C1X04_RS02860 620090..620572 + 483 WP_137169119.1 Hsp20 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12368.38 Da        Isoelectric Point: 8.3661

>T92635 WP_110575961.1 NZ_CP025987:616292-616609 [Marinomonas sp. FW-1]
MVIVETPIFTKLINEIMSDDEYKELQEALVIKPDLGVLIKNSGGLRKIRWSVDGRGKRGGIRIIYYWMTENEQLYMMYIF
PKNTQENLTDAQTKALRQIVERWSQ

Download         Length: 318 bp

>T92635 NZ_CP025987:616292-616609 [Marinomonas sp. FW-1]
ATGGTAATTGTTGAAACACCCATTTTCACCAAACTTATTAATGAAATAATGAGCGACGATGAATACAAGGAATTGCAGGA
AGCTTTGGTTATAAAGCCAGATCTTGGTGTGTTGATTAAAAACAGTGGTGGTTTAAGGAAGATTCGCTGGTCTGTGGACG
GTCGTGGGAAAAGGGGTGGCATACGAATCATCTATTACTGGATGACTGAGAATGAGCAGCTTTACATGATGTATATTTTT
CCTAAAAACACACAAGAAAACTTAACCGATGCGCAAACCAAAGCGCTAAGACAAATAGTAGAAAGGTGGTCACAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10674.11 Da        Isoelectric Point: 7.2040

>AT92635 WP_110575959.1 NZ_CP025987:616606-616896 [Marinomonas sp. FW-1]
MNDDMFNELLESVQQADSIIKGQNIAARITEFADPEVKAIRTKTGLSQSRFANLLGVSKRTLENWEQGRRHPTGPARALL
KIVDADPEYALKALHG

Download         Length: 291 bp

>AT92635 NZ_CP025987:616606-616896 [Marinomonas sp. FW-1]
ATGAATGACGACATGTTCAATGAATTGCTGGAAAGCGTACAACAAGCCGATAGCATCATAAAAGGCCAAAATATAGCGGC
ACGAATTACGGAATTTGCAGACCCAGAAGTGAAGGCTATTCGCACCAAAACAGGCCTAAGTCAAAGTCGTTTTGCTAACT
TGCTTGGTGTCAGTAAACGTACGTTAGAAAACTGGGAGCAAGGTCGCCGTCACCCAACTGGACCAGCACGAGCTTTGCTT
AAAATCGTCGATGCCGACCCAGAGTATGCGCTGAAAGCGCTGCATGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References