Detailed information of TA system TA092623

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2719623..2719848
• Replicon: chromosome
• Accession: NZ_CP025979
• Organism: Escherichia marmotae strain HT073016

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: C1192_RS14050
• Protein ID: WP_000887491.1
• Coordinates: 2719636..2719848 (+)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2719623..2719681 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1192_RS14000	2714632..2714832	+	201	WP_000159335.1	hypothetical protein	-
C1192_RS14005	2714801..2715177	-	377	Protein_2603	hypothetical protein	-
C1192_RS14010	2715177..2715329	-	153	WP_000379591.1	DUF1391 family protein	-
C1192_RS14015	2715496..2715903	-	408	WP_038354783.1	DNA-binding transcriptional dual regulator DicA	-
C1192_RS14020	2715987..2716217	+	231	WP_000920568.1	dicB transcriptional regulator DicC	-
C1192_RS14025	2716201..2716722	+	522	WP_038354782.1	hypothetical protein	-
C1192_RS14030	2716703..2717668	+	966	WP_038354781.1	phage O protein family	-
C1192_RS14035	2717709..2718131	+	423	WP_001151183.1	DUF977 family protein	-
C1192_RS14040	2718128..2718361	+	234	WP_001366387.1	hypothetical protein	-
C1192_RS14045	2718415..2719080	+	666	WP_001595803.1	epoxyqueuosine reductase QueH	-
-	2719623..2719681	-	59	-	-	Antitoxin
C1192_RS14050	2719636..2719848	+	213	WP_000887491.1	type I toxin-antitoxin system Hok family toxin	Toxin
C1192_RS14055	2720065..2720301	+	237	WP_000980998.1	hypothetical protein	-
C1192_RS14065	2720351..2720662	+	312	Protein_2614	IS66 family insertion sequence element accessory protein TnpB	-
C1192_RS14070	2720676..2722004	-	1329	WP_103194807.1	IS4 family transposase	-
C1192_RS14075	2722126..2723064	-	939	WP_010377442.1	malate dehydrogenase	-
C1192_RS14080	2723499..2723969	+	471	WP_001257843.1	transcriptional regulator ArgR	-
C1192_RS14085	2724334..2724597	+	264	WP_000695690.1	peroxide/acid stress response protein YhcN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2705503..2720665	15162

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7857.40 Da
• Isoelectric Point: 8.2634

>T92623 WP_000887491.1 NZ_CP025979:2719636-2719848 [Escherichia marmotae]
MLDTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 213 bp

>T92623 NZ_CP025979:2719636-2719848 [Escherichia marmotae]
ATGCTAGACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTACGAATCC
GAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT92623 NZ_CP025979:c2719681-2719623 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Antitoxin