Detailed information of TA system TA092621

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2505578..2505836
• Replicon: chromosome
• Accession: NZ_CP025979
• Organism: Escherichia marmotae strain HT073016

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: C1192_RS12890
• Protein ID: WP_077777495.1
• Coordinates: 2505627..2505836 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2505578..2505635 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1192_RS12860	2501333..2502274	-	942	WP_000767344.1	bifunctional riboflavin kinase/FAD synthetase	-
C1192_RS12865	2502282..2502500	-	219	Protein_2395	DUF2575 domain-containing protein	-
C1192_RS12870	2502603..2502866	+	264	WP_001274018.1	30S ribosomal protein S20	-
C1192_RS12875	2502969..2503874	-	906	WP_000062876.1	transcriptional activator NhaR	-
C1192_RS12880	2503934..2505100	-	1167	WP_000681378.1	Na+/H+ antiporter NhaA	-
-	2505578..2505635	-	58	-	-	Antitoxin
C1192_RS12890	2505627..2505836	+	210	WP_077777495.1	type I toxin-antitoxin system Hok family toxin	Toxin
C1192_RS12895	2505941..2507071	-	1131	WP_038354928.1	molecular chaperone DnaJ	-
C1192_RS12900	2507160..2509076	-	1917	WP_000516135.1	molecular chaperone DnaK	-
C1192_RS12905	2509453..2509705	+	253	Protein_2402	DUF2541 family protein	-
C1192_RS12910	2509945..2510511	+	567	WP_000528538.1	acetate uptake transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7714.23 Da
• Isoelectric Point: 9.3680

>T92621 WP_077777495.1 NZ_CP025979:2505627-2505836 [Escherichia marmotae]
MLNTCRVPLTDRKVKEKRAMKQHKAMIAALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T92621 NZ_CP025979:2505627-2505836 [Escherichia marmotae]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGCCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT92621 NZ_CP025979:c2505635-2505578 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin