Detailed information of TA system TA092608

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 824961..825186
• Replicon: chromosome
• Accession: NZ_CP025979
• Organism: Escherichia marmotae strain HT073016

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: C1192_RS04460
• Protein ID: WP_000887491.1
• Coordinates: 824974..825186 (+)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	824961..825019 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1192_RS04410	819970..820170	+	201	WP_000159335.1	hypothetical protein	-
C1192_RS04415	820139..820515	-	377	Protein_817	hypothetical protein	-
C1192_RS04420	820515..820667	-	153	WP_000379591.1	DUF1391 family protein	-
C1192_RS04425	820834..821241	-	408	WP_038354783.1	DNA-binding transcriptional dual regulator DicA	-
C1192_RS04430	821325..821555	+	231	WP_000920568.1	dicB transcriptional regulator DicC	-
C1192_RS04435	821539..822060	+	522	WP_038354782.1	hypothetical protein	-
C1192_RS04440	822041..823006	+	966	WP_038354781.1	phage O protein family	-
C1192_RS04445	823047..823469	+	423	WP_001151183.1	DUF977 family protein	-
C1192_RS04450	823466..823699	+	234	WP_001366387.1	hypothetical protein	-
C1192_RS04455	823753..824418	+	666	WP_001595803.1	epoxyqueuosine reductase QueH	-
-	824961..825019	-	59	-	-	Antitoxin
C1192_RS04460	824974..825186	+	213	WP_000887491.1	type I toxin-antitoxin system Hok family toxin	Toxin
C1192_RS04465	825403..825639	+	237	WP_000980998.1	hypothetical protein	-
C1192_RS04475	825689..826000	+	312	Protein_828	IS66 family insertion sequence element accessory protein TnpB	-
C1192_RS04480	826014..827342	-	1329	WP_103194771.1	IS4-like element IS4 family transposase	-
C1192_RS04485	827427..827804	+	378	Protein_830	transposase	-
C1192_RS04490	827804..828151	+	348	WP_069906977.1	IS66 family insertion sequence element accessory protein TnpB	-
C1192_RS04495	828171..829742	+	1572	WP_001756948.1	IS66 family transposase	-
C1192_RS04505	829866..830144	+	279	WP_023147795.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	809570..857553	47983

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7857.40 Da
• Isoelectric Point: 8.2634

>T92608 WP_000887491.1 NZ_CP025979:824974-825186 [Escherichia marmotae]
MLDTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 213 bp

>T92608 NZ_CP025979:824974-825186 [Escherichia marmotae]
ATGCTAGACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTACGAATCC
GAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT92608 NZ_CP025979:c825019-824961 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Antitoxin