Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1428772..1429430 Replicon chromosome
Accession NZ_CP025933
Organism Morganella morganii strain KC-Tt-01

Toxin (Protein)


Gene name higB Uniprot ID A0A447J593
Locus tag C1O70_RS06480 Protein ID WP_032098584.1
Coordinates 1428772..1429125 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J7TDD0
Locus tag C1O70_RS06485 Protein ID WP_004236876.1
Coordinates 1429128..1429430 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1O70_RS06470 1426952..1427209 - 258 WP_004236879.1 biofilm formation regulator BssS -
C1O70_RS06475 1427443..1428495 - 1053 WP_032098583.1 dihydroorotase -
C1O70_RS06480 1428772..1429125 + 354 WP_032098584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1O70_RS06485 1429128..1429430 + 303 WP_004236876.1 XRE family transcriptional regulator Antitoxin
C1O70_RS06510 1430539..1431048 - 510 WP_102831049.1 YlaC family protein -
C1O70_RS06515 1431509..1431721 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
C1O70_RS06520 1431825..1432019 + 195 WP_015422621.1 protein DsrB -
C1O70_RS06525 1432369..1433064 + 696 WP_032098586.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.58 Da        Isoelectric Point: 9.9631

>T92499 WP_032098584.1 NZ_CP025933:1428772-1429125 [Morganella morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T92499 NZ_CP025933:1428772-1429125 [Morganella morganii]
GTGTGGAAGATAGTCACAACAGATAATTTTACAGCGTGGTTTGCTGAGCAGGATGACGGAGATCGCGCAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGCGGGGACCCGGCTTACCAAGGCCGTATGCGGATACTGTAAAAGGTTCCCGGTATACGA
ATATGAAAGAGCTTCGTATACAGAGCAGGGGACAACCGATACGGGCATTTTTTGCATTCGACCCTGAGAGAAGAGGCGTC
TTGCTGTGTGCGGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATCCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11108.00 Da        Isoelectric Point: 9.5930

>AT92499 WP_004236876.1 NZ_CP025933:1429128-1429430 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT92499 NZ_CP025933:1429128-1429430 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTACTGGCTGAGGAAAAGCCGGAAGTCGCGGCTGCTGCACGGGTTCAGGCGGATGAGAT
CCTGCTGAATATCCATCTGGCGGAGCTGCGGGAGAAAGTGAAGAAAACACAGGTGGAAATGGCGCAGGCACTGGGAATAA
AACAGCCGACAGTCGCAGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGATGCCATC
GGCGGAAAACTGAATATTGATGTTGAACTGCCGGACGGCACGCATTATATGTTCCGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447J593

Antitoxin

Source ID Structure
AlphaFold DB J7TDD0

References