92498

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1496718..1497981 Replicon chromosome
Accession NZ_CP025932
Organism Porphyromonas gingivalis strain W83

Toxin (Protein)


Gene name HipT Uniprot ID Q7MW07
Locus tag CF003_RS17340 Protein ID WP_010956143.1
Coordinates 1496718..1497656 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q7MW08
Locus tag CF003_RS17345 Protein ID WP_005874041.1
Coordinates 1497646..1497981 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF003_RS17330 1492792..1496274 - 3483 WP_005874047.1 DEAD/DEAH box helicase family protein -
CF003_RS17335 1496328..1496648 - 321 WP_043876418.1 helix-turn-helix domain-containing protein -
CF003_RS17340 1496718..1497656 - 939 WP_010956143.1 HipA domain-containing protein Toxin
CF003_RS17345 1497646..1497981 - 336 WP_005874041.1 HipA N-terminal domain-containing protein Antitoxin
CF003_RS17350 1497978..1498202 - 225 WP_005874043.1 helix-turn-helix transcriptional regulator -
CF003_RS17355 1498426..1499331 - 906 WP_005874039.1 hypothetical protein -
CF003_RS17360 1499833..1500615 - 783 WP_004584112.1 DUF4393 domain-containing protein -
CF003_RS17365 1500652..1501137 - 486 WP_005874045.1 HU family DNA-binding protein -
CF003_RS17380 1501567..1502648 - 1082 Protein_1220 IS5 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(56-280)

Antitoxin

(6-101)


Sequences


Toxin        


Download         Length: 313 a.a.        Molecular weight: 36101.60 Da        Isoelectric Point: 6.1022

>T92498 WP_010956143.1 NZ_CP025932:c1497656-1496718 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI

Download         Length: 939 bp

>T92498 NZ_CP025932:c1497656-1496718 [Porphyromonas gingivalis]
ATGACGAATAGATGCCTATACTGCTACGAACCTTTGGTTGATGGAGAGATGGATTACCATGCCAAGTGTTGTCGCAAATT
GTTTGGGACGCCCCAAGCTCCTATATTGCCTTATACAAGTAGCGAAGTACGAGCGTTGGCTGACGAGGTCGTTCGTTCGC
AAACCACAGTGACAGGAGTACAACCCAAGCTATCTCTCGACTTTGACCAAATGAGCAATTCGCCCAAGCGATTTACCATC
GTGGGCTTGTGGGGACGGTTTATTCTTAAACCTCAAACAGAGCGTTATTCGCATCTCCCTGAATTGGAGGATGTGTCAAT
GCACCTTGCAGAGATTGCCAAGATAGAAACAGTTCCTCATGGACTGATGCGATTTAGCGATGGCGAACTATGCTATATCA
CTCGTCGCATAGACCGAACAGGGCAAGGGGAAAAGCTCCCAATGGAAGATATGTGCCAGCTCTCAGAGCGTCTGACCGAA
TATAAATACAAAGGCTCACACGAGCAGGTAGCCAAGCTGATCTCCAAGTATAGCTCTGTGCCAAAACTTGATCTTGTCAA
GTACTGGGAGCAGGTACTCTTTTCGTGGCTGATAGGTAATGCCGATATGCACCTCAAGAATTACTCGCTCTATGCTCCAG
AGGGAAATGAATATCAACTCACTCCAGCTTACGACCTGCTGTCTACGGCACTTGTTATTCCTGAGGATACAGAAGAACTT
GCATTGACCCTCTGTGGCAAAAAGCGCAAACTCACTCGCCAACACTTCCTCGAAGCGATGACAGCCTCAGGACTAGATGA
GAAAGTGTGTGACAATATTTTCGCTCGCTTCCAACACATCCTCCCCGAATGGGAAGCCTGCATCCGTCAGAGCTTCTTAC
CGACAGAGATGCAGAGACAATACATCGAATTTATTCTCCTCAAATTCTCTCAAATCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12679.49 Da        Isoelectric Point: 4.1551

>AT92498 WP_005874041.1 NZ_CP025932:c1497981-1497646 [Porphyromonas gingivalis]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE

Download         Length: 336 bp

>AT92498 NZ_CP025932:c1497981-1497646 [Porphyromonas gingivalis]
ATGAAACAGGCAATTGTTTATTGGAAGACACTCAAAGCAGGCATTCTCACAGAAAGTGATGAGGGCTATTCCTTTGCTTA
CGACAAGGACTATCTGACTATGCCCGAAGCTCAAGGCATAAGCCTAACAATGCCTTTGCGAGAAGAACCTTTCCAAAGCA
ATATGCTTCATCCATTTTTTGACGGACTTATCCCTGAGGGATGGCTGTTAGATATTGCTCAGAAGAATTGGAAGATAGAC
TCAAGGGATCGAATGGCTTTACTACTGGCTTGTTGCCGAGACTGCATTGGAGCGGTAAGTATCGAACCCCTAAATACGAC
TGAAGATGACGAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q7MW07


Antitoxin

Source ID Structure
AlphaFold DB Q7MW08

References