Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4764796..4765021 Replicon chromosome
Accession NZ_CP025920
Organism Escherichia coli strain 103605

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag CXW53_RS23695 Protein ID WP_000813254.1
Coordinates 4764866..4765021 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 4764796..4764854 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXW53_RS23665 4760261..4761538 + 1278 WP_000625667.1 DUF2254 domain-containing protein -
CXW53_RS23670 4761821..4762516 - 696 WP_032190252.1 hypothetical protein -
CXW53_RS23675 4762519..4763025 - 507 WP_000130123.1 hypothetical protein -
CXW53_RS23680 4763022..4763852 - 831 WP_001399639.1 ParA family protein -
- 4764796..4764854 - 59 - - Antitoxin
CXW53_RS23695 4764866..4765021 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
CXW53_RS23700 4765188..4765466 + 279 WP_001410105.1 hypothetical protein -
CXW53_RS23705 4765468..4766514 + 1047 WP_001265103.1 DUF968 domain-containing protein -
CXW53_RS23710 4766527..4766898 + 372 WP_001217451.1 RusA family crossover junction endodeoxyribonuclease -
CXW53_RS23715 4766888..4767241 + 354 WP_000532207.1 antitermination protein Q -
CXW53_RS23720 4767448..4768731 - 1284 WP_000123148.1 hypothetical protein -
CXW53_RS23725 4768988..4769182 + 195 WP_001355891.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4741636..4800740 59104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T92492 WP_000813254.1 NZ_CP025920:4764866-4765021 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T92492 NZ_CP025920:4764866-4765021 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT92492 NZ_CP025920:c4764854-4764796 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References