Detailed information of TA system TA092469

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1628745..1629157
• Replicon: chromosome
• Accession: NZ_CP025920
• Organism: Escherichia coli strain 103605

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A3W4M8W4
• Locus tag: CXW53_RS08200
• Protein ID: WP_000132864.1
• Coordinates: 1628816..1629157 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1628745..1628821 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXW53_RS08190	1625689..1627278	+	1590	WP_001063214.1	type I restriction-modification system methyltransferase	-
CXW53_RS08195	1627275..1628588	+	1314	WP_000042302.1	restriction endonuclease subunit S	-
-	1628745..1628821	-	77	NuclAT_14	-	Antitoxin
-	1628745..1628821	-	77	NuclAT_14	-	Antitoxin
-	1628745..1628821	-	77	NuclAT_14	-	Antitoxin
-	1628745..1628821	-	77	NuclAT_14	-	Antitoxin
-	1628745..1628821	-	77	NuclAT_15	-	Antitoxin
-	1628745..1628821	-	77	NuclAT_15	-	Antitoxin
-	1628745..1628821	-	77	NuclAT_15	-	Antitoxin
-	1628745..1628821	-	77	NuclAT_15	-	Antitoxin
CXW53_RS08200	1628816..1629157	+	342	WP_000132864.1	endoribonuclease SymE	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12254.06 Da
• Isoelectric Point: 7.8817

>T92469 WP_000132864.1 NZ_CP025920:1628816-1629157 [Escherichia coli]
MTDTYSIAQPFEAEVSPANNRHVTVGYASRYPDHAHIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRRVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T92469 NZ_CP025920:1628816-1629157 [Escherichia coli]
ATGACTGACACGTATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGCCGCTACCCGGATCACGCGCATATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGCATCGTCCTCACCGCTCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCAGGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT92469 NZ_CP025920:c1628821-1628745 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3W4M8W4

Antitoxin