Detailed information of TA system TA092460

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3638..3863
• Replicon: chromosome
• Accession: NZ_CP025920
• Organism: Escherichia coli strain 103605

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: CXW53_RS00045
• Protein ID: WP_000813254.1
• Coordinates: 3638..3793 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3805..3863 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXW53_RS00025	938..1759	-	822	WP_000762892.1	antitermination protein	-
CXW53_RS00030	1756..2136	-	381	WP_000140028.1	RusA family crossover junction endodeoxyribonuclease	-
CXW53_RS00035	2178..3192	-	1015	Protein_3	DUF968 domain-containing protein	-
CXW53_RS00040	3199..3471	-	273	Protein_4	hypothetical protein	-
CXW53_RS00045	3638..3793	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3805..3863	+	59	-	-	Antitoxin
CXW53_RS00055	4417..5226	+	810	WP_000161640.1	hypothetical protein	-
CXW53_RS00060	5373..5795	-	423	WP_001151221.1	DUF977 family protein	-
CXW53_RS00065	5836..6906	-	1071	WP_089516821.1	phage replisome organizer	-
CXW53_RS00070	6978..7403	-	426	WP_000693867.1	Rha family transcriptional regulator	-
CXW53_RS00075	7387..7629	-	243	WP_000747951.1	hypothetical protein	-
CXW53_RS00080	8021..8359	+	339	WP_001397087.1	peptidase S24-like family protein	-
CXW53_RS00085	8652..8807	+	156	WP_071608135.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	938..62202	61264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T92460 WP_000813254.1 NZ_CP025920:c3793-3638 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T92460 NZ_CP025920:c3793-3638 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT92460 NZ_CP025920:3805-3863 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin