Detailed information of TA system TA092393

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3964048..3964273
• Replicon: chromosome
• Accession: NZ_CP025910
• Organism: Escherichia coli strain 204446

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: CXW77_RS19575
• Protein ID: WP_000813254.1
• Coordinates: 3964048..3964203 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3964215..3964273 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXW77_RS27115	3959094..3959255	-	162	WP_001355909.1	hypothetical protein	-
CXW77_RS19525	3959252..3959440	-	189	WP_000874243.1	DUF1737 domain-containing protein	-
CXW77_RS19530	3959701..3960036	+	336	WP_000871291.1	anti-adapter protein IraM	-
CXW77_RS19535	3960317..3960448	-	132	WP_000562553.1	DUF3927 family protein	-
CXW77_RS19555	3961344..3962165	-	822	WP_000762892.1	antitermination protein	-
CXW77_RS19560	3962162..3962542	-	381	WP_000140028.1	RusA family crossover junction endodeoxyribonuclease	-
CXW77_RS19565	3962543..3963601	-	1059	WP_001736257.1	DUF968 domain-containing protein	-
CXW77_RS19570	3963603..3963881	-	279	WP_001410105.1	hypothetical protein	-
CXW77_RS19575	3964048..3964203	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3964215..3964273	+	59	-	-	Antitoxin
CXW77_RS19585	3964828..3965637	+	810	WP_000161640.1	hypothetical protein	-
CXW77_RS19590	3965784..3966206	-	423	WP_001151221.1	DUF977 family protein	-
CXW77_RS19595	3966247..3967317	-	1071	WP_089516821.1	phage replisome organizer	-
CXW77_RS19600	3967389..3967814	-	426	WP_000693867.1	Rha family transcriptional regulator	-
CXW77_RS19605	3967798..3968041	-	244	Protein_3759	hypothetical protein	-
CXW77_RS19610	3968433..3968771	+	339	WP_001397087.1	peptidase S24-like family protein	-
CXW77_RS19615	3969064..3969219	+	156	WP_071608135.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3931049..3976311	45262

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T92393 WP_000813254.1 NZ_CP025910:c3964203-3964048 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T92393 NZ_CP025910:c3964203-3964048 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT92393 NZ_CP025910:3964215-3964273 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin