Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3591287..3591512 Replicon chromosome
Accession NZ_CP025910
Organism Escherichia coli strain 204446

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag CXW77_RS17760 Protein ID WP_000813254.1
Coordinates 3591357..3591512 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 3591287..3591345 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXW77_RS17730 3586752..3588029 + 1278 WP_000625667.1 DUF2254 domain-containing protein -
CXW77_RS17735 3588312..3589007 - 696 WP_032190252.1 hypothetical protein -
CXW77_RS17740 3589010..3589516 - 507 WP_000130123.1 hypothetical protein -
CXW77_RS17745 3589513..3590343 - 831 WP_001399639.1 ParA family protein -
- 3591287..3591345 - 59 - - Antitoxin
CXW77_RS17760 3591357..3591512 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
CXW77_RS17765 3591679..3591957 + 279 WP_001410105.1 hypothetical protein -
CXW77_RS17770 3591959..3593005 + 1047 WP_001265103.1 DUF968 domain-containing protein -
CXW77_RS17775 3593018..3593389 + 372 WP_001217451.1 RusA family crossover junction endodeoxyribonuclease -
CXW77_RS17780 3593379..3593732 + 354 WP_000532207.1 antitermination protein Q -
CXW77_RS17785 3593939..3595222 - 1284 WP_000123148.1 hypothetical protein -
CXW77_RS17790 3595479..3595673 + 195 WP_001355891.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3565688..3629883 64195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T92390 WP_000813254.1 NZ_CP025910:3591357-3591512 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T92390 NZ_CP025910:3591357-3591512 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT92390 NZ_CP025910:c3591345-3591287 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References