Detailed information of TA system TA092368

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 453972..454384
• Replicon: chromosome
• Accession: NZ_CP025910
• Organism: Escherichia coli strain 204446

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A3W4M8W4
• Locus tag: CXW77_RS02255
• Protein ID: WP_000132864.1
• Coordinates: 454043..454384 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	453972..454048 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXW77_RS02245	450916..452505	+	1590	WP_001063214.1	type I restriction-modification system methyltransferase	-
CXW77_RS02250	452502..453815	+	1314	WP_000042302.1	restriction endonuclease subunit S	-
-	453972..454048	-	77	NuclAT_14	-	Antitoxin
-	453972..454048	-	77	NuclAT_14	-	Antitoxin
-	453972..454048	-	77	NuclAT_14	-	Antitoxin
-	453972..454048	-	77	NuclAT_14	-	Antitoxin
-	453972..454048	-	77	NuclAT_15	-	Antitoxin
-	453972..454048	-	77	NuclAT_15	-	Antitoxin
-	453972..454048	-	77	NuclAT_15	-	Antitoxin
-	453972..454048	-	77	NuclAT_15	-	Antitoxin
CXW77_RS02255	454043..454384	+	342	WP_000132864.1	endoribonuclease SymE	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12254.06 Da
• Isoelectric Point: 7.8817

>T92368 WP_000132864.1 NZ_CP025910:454043-454384 [Escherichia coli]
MTDTYSIAQPFEAEVSPANNRHVTVGYASRYPDHAHIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRRVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T92368 NZ_CP025910:454043-454384 [Escherichia coli]
ATGACTGACACGTATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGCCGCTACCCGGATCACGCGCATATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGCATCGTCCTCACCGCTCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCAGGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT92368 NZ_CP025910:c454048-453972 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3W4M8W4

Antitoxin