Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4704508..4705049 Replicon chromosome
Accession NZ_CP025881
Organism Escherichia coli strain 503440

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag CXX05_RS23365 Protein ID WP_000615976.1
Coordinates 4704508..4704786 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag CXX05_RS23370 Protein ID WP_000729704.1
Coordinates 4704789..4705049 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX05_RS23350 4702090..4702668 + 579 WP_001716156.1 D-sedoheptulose 7-phosphate isomerase -
CXX05_RS23355 4702874..4703641 + 768 WP_000333380.1 class II glutamine amidotransferase -
CXX05_RS23360 4703612..4704352 - 741 WP_001225679.1 murein L,D-transpeptidase -
CXX05_RS23365 4704508..4704786 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
CXX05_RS23370 4704789..4705049 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
CXX05_RS23375 4705235..4706008 + 774 WP_000543895.1 C40 family peptidase -
CXX05_RS23380 4706065..4706421 - 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
CXX05_RS23385 4706414..4706692 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
CXX05_RS23390 4706797..4708509 - 1713 Protein_4461 flagellar biosynthesis protein FlhA -
CXX05_RS23395 4708481..4709266 + 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 4695559..4706692 11133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T92315 WP_000615976.1 NZ_CP025881:c4704786-4704508 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T92315 NZ_CP025881:c4704786-4704508 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT92315 WP_000729704.1 NZ_CP025881:c4705049-4704789 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT92315 NZ_CP025881:c4705049-4704789 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References