Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2135795..2136020 Replicon chromosome
Accession NZ_CP025862
Organism Escherichia coli strain 504237

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag CXX10_RS10515 Protein ID WP_000813254.1
Coordinates 2135795..2135950 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2135962..2136020 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX10_RS10485 2131634..2131828 - 195 WP_001355891.1 hypothetical protein -
CXX10_RS10490 2132085..2133368 + 1284 WP_000123148.1 hypothetical protein -
CXX10_RS10495 2133575..2133928 - 354 WP_000532207.1 antitermination protein Q -
CXX10_RS10500 2133918..2134289 - 372 WP_001217451.1 RusA family crossover junction endodeoxyribonuclease -
CXX10_RS10505 2134302..2135348 - 1047 WP_126123775.1 DUF968 domain-containing protein -
CXX10_RS10510 2135350..2135628 - 279 WP_001410105.1 hypothetical protein -
CXX10_RS10515 2135795..2135950 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 2135962..2136020 + 59 - - Antitoxin
CXX10_RS10530 2136964..2137794 + 831 WP_001399639.1 ParA family protein -
CXX10_RS10535 2137791..2138297 + 507 WP_000130123.1 hypothetical protein -
CXX10_RS10540 2138300..2138995 + 696 WP_032190252.1 hypothetical protein -
CXX10_RS10545 2139278..2140555 - 1278 WP_000625667.1 DUF2254 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2100076..2155273 55197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T92222 WP_000813254.1 NZ_CP025862:c2135950-2135795 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T92222 NZ_CP025862:c2135950-2135795 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT92222 NZ_CP025862:2135962-2136020 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References