Detailed information of TA system TA092219

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1763034..1763259
• Replicon: chromosome
• Accession: NZ_CP025862
• Organism: Escherichia coli strain 504237

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: CXX10_RS08685
• Protein ID: WP_000813254.1
• Coordinates: 1763104..1763259 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1763034..1763092 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX10_RS08645	1758088..1758243	-	156	WP_071608135.1	DUF1391 family protein	-
CXX10_RS08650	1758536..1758874	-	339	WP_001397087.1	peptidase S24-like family protein	-
CXX10_RS08655	1759266..1759509	+	244	Protein_1663	hypothetical protein	-
CXX10_RS08660	1759493..1759918	+	426	WP_000693867.1	Rha family transcriptional regulator	-
CXX10_RS08665	1759990..1761060	+	1071	WP_089516821.1	phage replisome organizer	-
CXX10_RS08670	1761101..1761523	+	423	WP_001151221.1	DUF977 family protein	-
CXX10_RS08675	1761670..1762479	-	810	WP_000161640.1	hypothetical protein	-
-	1763034..1763092	-	59	-	-	Antitoxin
CXX10_RS08685	1763104..1763259	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
CXX10_RS08690	1763426..1763704	+	279	WP_001410105.1	hypothetical protein	-
CXX10_RS08695	1763706..1764764	+	1059	WP_001736257.1	DUF968 domain-containing protein	-
CXX10_RS08700	1764765..1765145	+	381	WP_000140028.1	RusA family crossover junction endodeoxyribonuclease	-
CXX10_RS08705	1765142..1765963	+	822	WP_000762892.1	antitermination protein	-
CXX10_RS08725	1766859..1766990	+	132	WP_000562553.1	DUF3927 family protein	-
CXX10_RS08730	1767271..1767606	-	336	WP_000871291.1	anti-adapter protein IraM	-
CXX10_RS08735	1767867..1768055	+	189	WP_000874243.1	DUF1737 domain-containing protein	-
CXX10_RS26115	1768052..1768213	+	162	WP_001355909.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1750996..1798064	47068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T92219 WP_000813254.1 NZ_CP025862:1763104-1763259 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T92219 NZ_CP025862:1763104-1763259 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT92219 NZ_CP025862:c1763092-1763034 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin