Detailed information of TA system TA092211

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1603742..1603967
• Replicon: chromosome
• Accession: NZ_CP025862
• Organism: Escherichia coli strain 504237

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: CXX10_RS07800
• Protein ID: WP_000813254.1
• Coordinates: 1603812..1603967 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1603742..1603800 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX10_RS07760	1599052..1599279	+	228	WP_000476985.1	transcriptional regulator	-
CXX10_RS07765	1599263..1599784	+	522	WP_000705382.1	hypothetical protein	-
CXX10_RS07770	1599765..1600730	+	966	WP_000054517.1	hypothetical protein	-
CXX10_RS07775	1600736..1601482	+	747	WP_000788772.1	ATP-binding protein	-
CXX10_RS07780	1601504..1602265	+	762	WP_000450703.1	DUF1627 domain-containing protein	-
CXX10_RS07785	1602298..1602579	+	282	WP_001509842.1	hypothetical protein	-
CXX10_RS07790	1602582..1602994	+	413	Protein_1494	DUF4406 domain-containing protein	-
CXX10_RS07795	1603098..1603520	+	423	WP_000160146.1	hypothetical protein	-
-	1603742..1603800	-	59	-	-	Antitoxin
CXX10_RS07800	1603812..1603967	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
CXX10_RS07805	1604183..1604362	+	180	WP_001277775.1	hypothetical protein	-
CXX10_RS07810	1604381..1604866	+	486	WP_000818165.1	type II toxin-antitoxin system death-on-curing family toxin	-
CXX10_RS07815	1605067..1605327	+	261	WP_000701918.1	hypothetical protein	-
CXX10_RS07820	1605394..1605672	+	279	WP_023607105.1	hypothetical protein	-
CXX10_RS07825	1605674..1606729	+	1056	WP_001502278.1	DUF968 domain-containing protein	-
CXX10_RS07830	1606730..1607095	+	366	WP_001297842.1	RusA family crossover junction endodeoxyribonuclease	-
CXX10_RS07835	1607104..1607646	+	543	WP_001398904.1	DUF1133 family protein	-
CXX10_RS07840	1607959..1608156	+	198	WP_000917767.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1585110..1644358	59248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T92211 WP_000813254.1 NZ_CP025862:1603812-1603967 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T92211 NZ_CP025862:1603812-1603967 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT92211 NZ_CP025862:c1603800-1603742 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin