Detailed information of TA system TA092204

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 272425..272837
• Replicon: chromosome
• Accession: NZ_CP025862
• Organism: Escherichia coli strain 504237

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A3W4M8W4
• Locus tag: CXX10_RS01380
• Protein ID: WP_000132864.1
• Coordinates: 272425..272766 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	272761..272837 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX10_RS01380	272425..272766	-	342	WP_000132864.1	endoribonuclease SymE	Toxin
-	272761..272837	+	77	NuclAT_14	-	Antitoxin
-	272761..272837	+	77	NuclAT_14	-	Antitoxin
-	272761..272837	+	77	NuclAT_14	-	Antitoxin
-	272761..272837	+	77	NuclAT_14	-	Antitoxin
-	272761..272837	+	77	NuclAT_15	-	Antitoxin
-	272761..272837	+	77	NuclAT_15	-	Antitoxin
-	272761..272837	+	77	NuclAT_15	-	Antitoxin
-	272761..272837	+	77	NuclAT_15	-	Antitoxin
CXX10_RS01385	272994..274307	-	1314	WP_000042302.1	restriction endonuclease subunit S	-
CXX10_RS01390	274304..275893	-	1590	WP_001063214.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12254.06 Da
• Isoelectric Point: 7.8817

>T92204 WP_000132864.1 NZ_CP025862:c272766-272425 [Escherichia coli]
MTDTYSIAQPFEAEVSPANNRHVTVGYASRYPDHAHIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRRVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T92204 NZ_CP025862:c272766-272425 [Escherichia coli]
ATGACTGACACGTATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGCCGCTACCCGGATCACGCGCATATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGCATCGTCCTCACCGCTCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCAGGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT92204 NZ_CP025862:272761-272837 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3W4M8W4

Antitoxin