Detailed information of TA system TA092163

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1701..1954
• Replicon: plasmid p504838_108
• Accession: NZ_CP025857
• Organism: Escherichia coli strain 504838

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: A0A148HBD8
• Locus tag: CXV93_RS25420
• Protein ID: WP_001336447.1
• Coordinates: 1701..1850 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	1898..1954 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXV93_RS25400	1..858	-	858	WP_001537577.1	incFII family plasmid replication initiator RepA	-
CXV93_RS25405	851..925	-	75	WP_001365705.1	RepA leader peptide Tap	-
CXV93_RS25415	1159..1416	-	258	WP_000084404.1	replication regulatory protein RepA	-
CXV93_RS25420	1701..1850	-	150	WP_001336447.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	1898..1954	+	57	NuclAT_2	-	Antitoxin
-	1898..1954	+	57	NuclAT_2	-	Antitoxin
-	1898..1954	+	57	NuclAT_2	-	Antitoxin
-	1898..1954	+	57	NuclAT_2	-	Antitoxin
CXV93_RS25430	2049..2486	-	438	WP_000872609.1	hypothetical protein	-
CXV93_RS25435	2639..3022	-	384	WP_001109264.1	hypothetical protein	-
CXV93_RS25440	3084..3781	+	698	Protein_6	IS1 family transposase	-
CXV93_RS25445	3902..4363	-	462	WP_000760080.1	thermonuclease family protein	-
CXV93_RS25450	5116..5319	-	204	WP_001336517.1	hypothetical protein	-
CXV93_RS25455	5471..6028	-	558	WP_000139329.1	fertility inhibition protein FinO	-
CXV93_RS25460	6083..6829	-	747	WP_000205709.1	conjugal transfer pilus acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	cofA	1..108475	108475
	-	flank	IS/Tn	-	-	3404..3781	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5572.69 Da
• Isoelectric Point: 8.7678

>T92163 WP_001336447.1 NZ_CP025857:c1850-1701 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T92163 NZ_CP025857:c1850-1701 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT92163 NZ_CP025857:1898-1954 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A148HBD8

Antitoxin