Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4953375..4953877 Replicon chromosome
Accession NZ_CP025856
Organism Escherichia coli strain 504838

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CXV93_RS24495 Protein ID WP_000767835.1
Coordinates 4953623..4953877 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag CXV93_RS24490 Protein ID WP_001259255.1
Coordinates 4953375..4953626 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXV93_RS24465 4948552..4949619 - 1068 WP_000080072.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
CXV93_RS24470 4949619..4950689 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
CXV93_RS24475 4950686..4951990 - 1305 WP_001356284.1 histidinol dehydrogenase -
CXV93_RS24480 4951996..4952895 - 900 WP_000131774.1 ATP phosphoribosyltransferase -
CXV93_RS24485 4953041..4953091 - 51 WP_001364200.1 his operon leader peptide -
CXV93_RS24490 4953375..4953626 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CXV93_RS24495 4953623..4953877 + 255 WP_000767835.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CXV93_RS24500 4953960..4954784 + 825 WP_000754737.1 SDR family oxidoreductase -
CXV93_RS24505 4954830..4955759 + 930 WP_000803351.1 LysR family transcriptional regulator -
CXV93_RS24510 4955974..4956036 + 63 WP_010723108.1 membrane protein YoeI -
CXV93_RS24515 4956026..4957384 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CXV93_RS24520 4957563..4958621 + 1059 WP_000492320.1 transport protein YeeE -
CXV93_RS24525 4958635..4958862 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.51 Da        Isoelectric Point: 7.2751

>T92161 WP_000767835.1 NZ_CP025856:4953623-4953877 [Escherichia coli]
VKLIWSEESWDDYLYWQETDNRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T92161 NZ_CP025856:4953623-4953877 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAATCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT92161 WP_001259255.1 NZ_CP025856:4953375-4953626 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT92161 NZ_CP025856:4953375-4953626 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References