Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1876537..1877078 Replicon chromosome
Accession NZ_CP025856
Organism Escherichia coli strain 504838

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag CXV93_RS09430 Protein ID WP_000615976.1
Coordinates 1876800..1877078 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag CXV93_RS09425 Protein ID WP_000729704.1
Coordinates 1876537..1876797 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXV93_RS09400 1872320..1873105 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
CXV93_RS09405 1873077..1874789 + 1713 Protein_1814 flagellar biosynthesis protein FlhA -
CXV93_RS09410 1874894..1875172 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
CXV93_RS09415 1875165..1875521 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
CXV93_RS09420 1875578..1876351 - 774 WP_122996850.1 C40 family peptidase -
CXV93_RS09425 1876537..1876797 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
CXV93_RS09430 1876800..1877078 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
CXV93_RS09435 1877234..1877974 + 741 WP_001225679.1 murein L,D-transpeptidase -
CXV93_RS09440 1877945..1878712 - 768 WP_000333380.1 class II glutamine amidotransferase -
CXV93_RS09445 1878918..1879496 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T92152 WP_000615976.1 NZ_CP025856:1876800-1877078 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T92152 NZ_CP025856:1876800-1877078 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT92152 WP_000729704.1 NZ_CP025856:1876537-1876797 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT92152 NZ_CP025856:1876537-1876797 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References