Detailed information of TA system TA092062

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-istR/SymE(toxin)
• Location: 2492718..2493130
• Replicon: chromosome
• Accession: NZ_CP025847
• Organism: Escherichia coli strain 602354

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A3W4M8W4
• Locus tag: CXX15_RS12075
• Protein ID: WP_000132864.1
• Coordinates: 2492718..2493059 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	istR
Locus tag	-
Coordinates	2493054..2493130 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX15_RS12075	2492718..2493059	-	342	WP_000132864.1	endoribonuclease SymE	Toxin
-	2493054..2493130	+	77	NuclAT_14	-	Antitoxin
-	2493054..2493130	+	77	NuclAT_14	-	Antitoxin
-	2493054..2493130	+	77	NuclAT_14	-	Antitoxin
-	2493054..2493130	+	77	NuclAT_14	-	Antitoxin
-	2493054..2493130	+	77	NuclAT_15	-	Antitoxin
-	2493054..2493130	+	77	NuclAT_15	-	Antitoxin
-	2493054..2493130	+	77	NuclAT_15	-	Antitoxin
-	2493054..2493130	+	77	NuclAT_15	-	Antitoxin
CXX15_RS12080	2493287..2494600	-	1314	WP_000042302.1	restriction endonuclease subunit S	-
CXX15_RS12085	2494597..2496186	-	1590	WP_001063214.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2484372..2494600	10228

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12254.06 Da
• Isoelectric Point: 7.8817

>T92062 WP_000132864.1 NZ_CP025847:c2493059-2492718 [Escherichia coli]
MTDTYSIAQPFEAEVSPANNRHVTVGYASRYPDHAHIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRRVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T92062 NZ_CP025847:c2493059-2492718 [Escherichia coli]
ATGACTGACACGTATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGCCGCTACCCGGATCACGCGCATATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGCATCGTCCTCACCGCTCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCAGGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT92062 NZ_CP025847:2493054-2493130 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3W4M8W4

Antitoxin