Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1574857..1575369 Replicon chromosome
Accession NZ_CP025838
Organism Streptococcus pneumoniae strain SPN XDR SMC1710-32

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag C1H54_RS08495 Protein ID WP_000924721.1
Coordinates 1574857..1575111 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag C1H54_RS08500 Protein ID WP_000388572.1
Coordinates 1575115..1575369 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H54_RS08480 1571958..1572272 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
C1H54_RS08485 1572297..1572923 - 627 WP_000775037.1 guanylate kinase -
C1H54_RS08490 1573053..1574666 - 1614 WP_000404929.1 ribonuclease Y -
C1H54_RS08495 1574857..1575111 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
C1H54_RS08500 1575115..1575369 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1H54_RS08505 1575607..1576703 - 1097 Protein_1593 nucleotidyltransferase -
C1H54_RS08510 1576727..1578538 - 1812 WP_001025033.1 NACHT domain-containing protein -
C1H54_RS08515 1578579..1579319 - 741 WP_000257068.1 class I SAM-dependent methyltransferase -
C1H54_RS08520 1579639..1579992 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T92001 WP_000924721.1 NZ_CP025838:c1575111-1574857 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T92001 NZ_CP025838:c1575111-1574857 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT92001 WP_000388572.1 NZ_CP025838:c1575369-1575115 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT92001 NZ_CP025838:c1575369-1575115 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References