Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3015069..3015632 Replicon chromosome
Accession NZ_CP025781
Organism Iodobacter fluviatilis strain PCH194

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C1H71_RS13380 Protein ID WP_130106992.1
Coordinates 3015351..3015632 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag C1H71_RS13375 Protein ID WP_130106991.1
Coordinates 3015069..3015341 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H71_RS13360 3011862..3012593 + 732 WP_130106988.1 hypothetical protein -
C1H71_RS13365 3012590..3013141 + 552 WP_130106989.1 hypothetical protein -
C1H71_RS13370 3013141..3015066 + 1926 WP_130106990.1 phage terminase large subunit family protein -
C1H71_RS13375 3015069..3015341 - 273 WP_130106991.1 HigA family addiction module antidote protein Antitoxin
C1H71_RS13380 3015351..3015632 - 282 WP_130106992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1H71_RS13385 3015787..3016278 + 492 WP_130106993.1 hypothetical protein -
C1H71_RS13390 3016608..3016805 + 198 WP_130106994.1 hypothetical protein -
C1H71_RS13395 3017016..3017273 + 258 WP_130106995.1 hypothetical protein -
C1H71_RS13400 3017273..3018784 + 1512 WP_130106996.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2995726..3046297 50571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10625.15 Da        Isoelectric Point: 7.4741

>T91956 WP_130106992.1 NZ_CP025781:c3015632-3015351 [Iodobacter fluviatilis]
MIKSFKHKGLEAFFLTGSKAGIRPDHASKLNIVLTHLDVADCPQDMGTPSWRLHPLKGPLDQHWAVTINGNWRLTFRFLP
DGNVELVDYQDYH

Download         Length: 282 bp

>T91956 NZ_CP025781:c3015632-3015351 [Iodobacter fluviatilis]
ATGATTAAATCGTTCAAACACAAAGGCTTAGAAGCCTTCTTTTTGACCGGCAGCAAGGCTGGAATCCGCCCCGATCATGC
AAGCAAGCTCAACATTGTGCTGACCCATCTTGATGTGGCAGATTGCCCACAGGATATGGGCACCCCAAGCTGGCGCTTGC
ACCCACTAAAAGGCCCCCTGGACCAACACTGGGCAGTCACTATCAACGGCAACTGGCGGCTAACATTTCGTTTTTTGCCC
GATGGCAATGTCGAATTGGTTGATTACCAGGACTATCACTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10249.95 Da        Isoelectric Point: 8.7821

>AT91956 WP_130106991.1 NZ_CP025781:c3015341-3015069 [Iodobacter fluviatilis]
MRMHNPAHPGEVLQEWLIDISVTEAARKLGITRVHLSRILHGHMGISADMDLRLSASLGTTPGLWMKMQLNYDLWQAEQK
PRPQVERLVA

Download         Length: 273 bp

>AT91956 NZ_CP025781:c3015341-3015069 [Iodobacter fluviatilis]
ATGCGTATGCACAACCCAGCCCACCCCGGCGAAGTGCTTCAAGAATGGCTAATTGATATCAGTGTCACCGAAGCCGCCCG
CAAACTAGGTATTACCCGCGTCCATCTGTCACGCATTCTGCACGGCCATATGGGCATCAGTGCCGATATGGATTTGCGCC
TATCCGCTAGCCTTGGCACTACACCGGGACTCTGGATGAAAATGCAATTGAACTACGATCTGTGGCAAGCAGAACAAAAG
CCCCGACCACAAGTTGAGCGACTGGTCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References