Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2760083..2760776 Replicon chromosome
Accession NZ_CP025753
Organism Escherichia coli strain CV839-06

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag CV83906_RS15230 Protein ID WP_000415584.1
Coordinates 2760083..2760379 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CV83906_RS15235 Protein ID WP_000650107.1
Coordinates 2760381..2760776 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV83906_RS15200 2755758..2756072 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
CV83906_RS15205 2756103..2756684 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
CV83906_RS15210 2756794..2758143 - 1350 WP_000673406.1 two-component system sensor histidine kinase QseC -
CV83906_RS15215 2758140..2758799 - 660 WP_001221491.1 two-component system response regulator QseB -
CV83906_RS15220 2758951..2759343 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CV83906_RS15225 2759396..2759878 + 483 WP_000183498.1 GyrI-like domain-containing protein -
CV83906_RS15230 2760083..2760379 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
CV83906_RS15235 2760381..2760776 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CV83906_RS15245 2760909..2762516 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
CV83906_RS15250 2762654..2764912 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2748355..2760776 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T91914 WP_000415584.1 NZ_CP025753:2760083-2760379 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T91914 NZ_CP025753:2760083-2760379 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT91914 WP_000650107.1 NZ_CP025753:2760381-2760776 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT91914 NZ_CP025753:2760381-2760776 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATAATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References