Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2604020..2604819 Replicon chromosome
Accession NZ_CP025753
Organism Escherichia coli strain CV839-06

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag CV83906_RS14410 Protein ID WP_000347251.1
Coordinates 2604020..2604484 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag CV83906_RS14415 Protein ID WP_001307405.1
Coordinates 2604484..2604819 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV83906_RS14375 2599021..2599455 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
CV83906_RS14380 2599473..2600351 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CV83906_RS14385 2600341..2601120 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
CV83906_RS14390 2601131..2601604 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
CV83906_RS14395 2601627..2602907 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
CV83906_RS14405 2603156..2603965 + 810 WP_000072192.1 aga operon transcriptional regulator AgaR -
CV83906_RS14410 2604020..2604484 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
CV83906_RS14415 2604484..2604819 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
CV83906_RS14420 2604968..2606539 - 1572 WP_001273761.1 galactarate dehydratase -
CV83906_RS14425 2606914..2608248 + 1335 WP_000599653.1 galactarate/glucarate/glycerate transporter GarP -
CV83906_RS14430 2608264..2609034 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T91912 WP_000347251.1 NZ_CP025753:c2604484-2604020 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T91912 NZ_CP025753:c2604484-2604020 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT91912 WP_001307405.1 NZ_CP025753:c2604819-2604484 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT91912 NZ_CP025753:c2604819-2604484 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References