Detailed information of TA system TA091791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 2711063..2711665
• Replicon: chromosome
• Accession: NZ_CP025707
• Organism: Escherichia coli strain YDC107

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U9XIS6
• Locus tag: YDC107_RS13305
• Protein ID: WP_000897305.1
• Coordinates: 2711063..2711374 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: YDC107_RS13310
• Protein ID: WP_000356395.1
• Coordinates: 2711375..2711665 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YDC107_RS13285	2706104..2706541	+	438	WP_000560983.1	D-tyrosyl-tRNA(Tyr) deacylase	-
YDC107_RS13290	2706538..2707527	+	990	WP_000080791.1	fatty acid biosynthesis protein FabY	-
YDC107_RS13295	2707943..2709757	+	1815	WP_020233236.1	hypothetical protein	-
YDC107_RS13300	2709926..2710834	-	909	WP_001306651.1	alpha/beta hydrolase	-
YDC107_RS13305	2711063..2711374	+	312	WP_000897305.1	hypothetical protein	Toxin
YDC107_RS13310	2711375..2711665	+	291	WP_000356395.1	helix-turn-helix domain-containing protein	Antitoxin
YDC107_RS13315	2711750..2711962	+	213	WP_000197769.1	hypothetical protein	-
YDC107_RS13320	2712024..2712302	+	279	WP_001306650.1	hypothetical protein	-
YDC107_RS13325	2712342..2712525	+	184	Protein_2597	hypothetical protein	-
YDC107_RS13330	2712721..2712939	+	219	WP_001295676.1	ribbon-helix-helix domain-containing protein	-
YDC107_RS13335	2713158..2713400	+	243	WP_021523315.1	hypothetical protein	-
YDC107_RS13340	2713582..2714511	-	930	WP_000027708.1	formate dehydrogenase accessory protein FdhE	-
YDC107_RS13345	2714508..2715143	-	636	WP_000829013.1	formate dehydrogenase cytochrome b556 subunit	-
YDC107_RS13350	2715140..2716042	-	903	WP_000331377.1	formate dehydrogenase O subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12190.19 Da
• Isoelectric Point: 9.7791

>T91791 WP_000897305.1 NZ_CP025707:2711063-2711374 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Nucleotide

• Length: 312 bp

>T91791 NZ_CP025707:2711063-2711374 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10869.46 Da
• Isoelectric Point: 10.8907

>AT91791 WP_000356395.1 NZ_CP025707:2711375-2711665 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Nucleotide

• Length: 291 bp

>AT91791 NZ_CP025707:2711375-2711665 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: A0A0E0Y7I7