91770

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 875846..876448 Replicon chromosome
Accession NZ_CP025704
Organism Bacteriovorax stolpii strain DSM 12778

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C0V70_RS04135 Protein ID WP_102242608.1
Coordinates 876155..876448 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C0V70_RS04130 Protein ID WP_102242607.1
Coordinates 875846..876145 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0V70_RS04105 871776..872042 - 267 WP_102242602.1 helix-turn-helix domain-containing protein -
C0V70_RS04110 872323..872748 - 426 WP_102242603.1 hypothetical protein -
C0V70_RS04115 872849..873577 - 729 WP_102242604.1 SDR family oxidoreductase -
C0V70_RS04120 873687..874532 + 846 WP_102242605.1 restriction endonuclease -
C0V70_RS04125 874542..875849 + 1308 WP_102242606.1 MBL fold metallo-hydrolase -
C0V70_RS04130 875846..876145 - 300 WP_102242607.1 HigA family addiction module antidote protein Antitoxin
C0V70_RS04135 876155..876448 - 294 WP_102242608.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0V70_RS04140 876583..878397 - 1815 WP_102242609.1 M3 family oligoendopeptidase -
C0V70_RS04145 878548..879129 + 582 WP_102242610.1 GNAT family N-acetyltransferase -
C0V70_RS04150 879132..879821 + 690 WP_102242611.1 hypothetical protein -
C0V70_RS04155 879826..880332 - 507 WP_102242612.1 helix-turn-helix transcriptional regulator -
C0V70_RS04160 880342..881061 - 720 WP_102245443.1 cytochrome b/b6 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 834435..961241 126806


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-92)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11400.32 Da        Isoelectric Point: 8.9433

>T91770 WP_102242608.1 NZ_CP025704:c876448-876155 [Bacteriovorax stolpii]
MVIVSFREIQLQDFIETGIPPKNCQWKFLSKVVLRKLDMLNYAKRLDDLKAPPGNRLKALKGDLIGHYSIRINDQWRIIF
IWSEDGPANVEIVDYHF

Download         Length: 294 bp

>T91770 NZ_CP025704:c876448-876155 [Bacteriovorax stolpii]
ATGGTTATTGTCAGTTTCAGGGAGATTCAACTTCAAGATTTTATAGAAACGGGAATTCCTCCCAAGAATTGCCAATGGAA
ATTTTTATCTAAAGTAGTTTTAAGAAAGCTGGATATGTTAAACTACGCAAAACGGTTGGATGATTTAAAAGCTCCACCTG
GAAACAGGCTCAAAGCTCTTAAAGGTGATTTAATCGGTCATTACAGTATAAGAATTAACGACCAGTGGAGAATTATTTTT
ATCTGGAGTGAAGATGGTCCAGCGAATGTTGAAATAGTTGATTACCACTTTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11157.98 Da        Isoelectric Point: 9.4884

>AT91770 WP_102242607.1 NZ_CP025704:c876145-875846 [Bacteriovorax stolpii]
MNKINYQRPPTNPGEILSEEFLKPLGLTQKELADHIQVDIKVINRLVNGKTTLSAEMALKLASSFQTTPDFWLSAQYEID
LYRAKMSLPKLPGAIIKTN

Download         Length: 300 bp

>AT91770 NZ_CP025704:c876145-875846 [Bacteriovorax stolpii]
ATGAATAAAATAAACTATCAAAGACCACCGACGAATCCAGGAGAAATTCTTTCCGAAGAATTTTTAAAACCTTTGGGATT
AACTCAGAAAGAATTGGCCGACCATATACAAGTTGATATCAAAGTGATTAATCGACTGGTAAATGGAAAAACGACCTTAT
CTGCCGAAATGGCCTTAAAACTCGCTTCTTCTTTTCAAACGACGCCAGACTTCTGGCTATCGGCCCAATACGAAATTGAT
CTTTATAGAGCAAAAATGTCTCTTCCAAAACTTCCCGGCGCAATTATTAAGACTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References