Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 23910..24168 Replicon chromosome
Accession NZ_CP025703
Organism Escherichia coli strain BH100N substr. MG2017

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag BH100N_RS00130 Protein ID WP_000809168.1
Coordinates 23910..24062 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 24111..24168 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH100N_RS00110 19155..19868 - 714 WP_001102393.1 acidic protein MsyB -
BH100N_RS00115 19894..20298 - 405 WP_000843689.1 DUF2541 family protein -
BH100N_RS00120 20670..22586 + 1917 WP_000516135.1 molecular chaperone DnaK -
BH100N_RS00125 22675..23805 + 1131 WP_001118464.1 molecular chaperone DnaJ -
BH100N_RS00130 23910..24062 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 24111..24168 + 58 - - Antitoxin
BH100N_RS00140 24677..25438 + 762 WP_099989640.1 hypothetical protein -
BH100N_RS00145 25458..26951 + 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
BH100N_RS00150 27080..28339 + 1260 WP_000494927.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T91738 WP_000809168.1 NZ_CP025703:c24062-23910 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T91738 NZ_CP025703:c24062-23910 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT91738 NZ_CP025703:24111-24168 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References